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Set amid the mangrove swamps, coastal lagoons, and stretches of coral reef in Portobelo National Park, this Design Hotels property features just five colorful villas. The “houses” range from a small, one-bedroom retreat nestled near a waterfall, to an over 8,000-square-foot residence spread over two floors. The whole property is awash in a kaleidoscope of vibrant hues, from the bright interiors with their boldly patterned tiles, decorative fabrics, and local artwork, to the multi-colored lounge chairs surrounding the infinity pool, which seems to merge seamlessly with the turquoise Portobelo Bay. Those seeking adventure can take a deep-sea dive to explore the wreck of a C-45 airplane, while guests looking to relax can book an outdoor massage on the hotel’s century-old barge.

There’s truly no other place in the world like this unique and disturbing museum. It’s probably best that photography is strictly prohibited inside, because that might spoil the bizarre surprises that wait for those who haven’t been yet. The Mütter is a medical museum in Center City that’s part of the College of Physicians of Philadelphia. Be forewarned: Its world-renowned collections are often somewhat disquieting—biological oddities, anatomical and pathological specimens, wax models, and antique medical equipment. (Wooden cabinets in one gallery hold drawers full of objects that people have swallowed!) The gift shop may be the most interesting museum store you’ll ever visit, and might be the only place that sells conjoined-twin cookie cutters.

Since 1993, Philadelphians Wendy Born and James Barrett have shown a deft hand in the kitchens of their multi-location Metropolitan Bakery. Artisanal breads – able to rival any venerated loaf from Europe– are their claim to fame but their cookies, cakes, croissants and locally-sourced jams and spreads are equally as divine. They have several locations in Philadelphia, including my favorite in Chestnut Hill a bit further afield, but consistency is assured in each outpost. You can also expect to see the duo’s vision (and baked goods) played out at FARMiCiA, the organic/local restaurant they co-own in Old City. If you have a hankering for something sweet, don’t leave without picking up one of their toothsome chocolate chip cookies (or a few).

There is no better place for visitors interested in one-stop souvenir shopping than the Pennsylvania General Store, located inside the Reading Terminal Market. You’ll find everything from Amish quilts to just-made fudge, as well as food items unique to the region, including locally treasured Asher’s chocolate-covered pretzels. Also recommended are decadent, fresh-baked Hope’s Cookies, and tins of Rosie’s butterkins (butter cookies). If you’re not hungry, maybe you need a soft pretzel T-shirt, City of Brotherly Love shot glasses, or a bawdy coffee mug touting the town of Intercourse, Pennsylvania? Former Philadelphians who miss their regional treats can order care packages online from the General Store’s website.

Rather than diving right into the hard stuff, sip one of the 35 craft beers on tap at the new SLS hotel’s Umami Burger beer garden. Pair it with an Umami pork belly sausage, served only at these bar stools.

They intended it as their gift to Mexico, and what a gift it is. Diego Rivera and Frida Kahlo, two of the most famous artists of the 20th century, worked with renowned Mexican architect Juan O’Gorman to create Museo Anahuacalli, a temple-like structure that houses the 50,000+ pre-Hispanic objects Rivera collected during his lifetime. The museum, whose design was also influenced by Frank Lloyd Wright and his notions about the role of the physical environmental in the conceptualization and construction of buildings, also showcases hundreds of pieces of artisan and craft works representative of Mexico. Note that the museum is not open on Monday or Tuesday.

Set within a century-old, Pantheon-inspired former bank building, the Ritz-Carlton, Philadelphia raises Center City living to classical heights. When the building opened in 1904, the Girard Trust marble dome was the largest in the country, and its columns and styling matched its inspiration down to its oculus 142 feet from the floor, the exact height as the Roman original. Today, every stay starts in this grandiose rotunda, where staff man the immaculately preserved bank-teller booths. Guest rooms and suites are in the attached 30-story office tower, gutted and transformed into a hotel by Ritz-Carlton.

All 299 rooms and suites bring classic Ritz-Carlton elegance, with wood furnishings matching gold, sage, and pumpkin hues. High ceilings and picture windows with stunning city views enhance the vibe, while spa-style marble bathrooms have rain showers.

The bustling corner of Walnut and 17^th streets is anchored by the Latham, a stone-and-brick tower built in 1907 as luxury apartments for moneyed Philadelphians. While other Center City historic structures met their demise in the late 1960s, a group of investors doubled down on the stately building, transforming it into Philadelphia’s premier business hotel in 1970. The prestigious address completed a top-to-bottom renovation in 2011, bringing the Latham firmly into the 21st century while preserving period artifacts and style.

True to its apartment roots, arriving at the hotel is more like entering a tony doorman building, and the Latham’s residential roots bestow spacious guestrooms with tall ceilings, bay windows, and big bathrooms. Gold and gray hues are complemented by pops of blue, while big bathrooms keep it simple with a tub/shower combination.

Guidebooks often lack the practical pieces of advice that could save travelers some rather unpleasant moments, in the Greek Islands one such nugget of wisdom I missed in my reading was that after a late night fueled by Ouzo it is not ideal to ride in a high speed ferry. Thankfully the ferry ride from Mykonos to Naxos is a short one at under an hour. I was greeted at the terminal by part of the family that runs Hotel Grotto, a small retreat perched on the edge of the Aegean sea that would be my home while in Naxos. After weeks competing for beach chairs and being corralled down tight marble alleys in some of the more frequented islands, Hora (also known as Naxos Town) proved the perfect place to relax and experience Greece at a slower pace. Upon arriving to the hotel, the bags were taken out of my hand and replaced with a glass of wine made by “Pappa” along with local olives as I was led out to the pictured patio. The view from patio of the hotel is of the Portara, believed to be the beginning of the Temple of Apollo dated back to 530 BC and is an ideal spot to pack a picnic from the local grocery, and watch the sunset before heading into town for the night. On the walk back to the hotel rising above the town is The Venetian Castle Kastro. During the day it serves as a museum offering tours, on Sunday nights after sunset it hosts traditional music and dance made easier by the accompaniment of Kitron,a liqueur indigineous to the area.

This huge buffet restaurant, designed to look like an old hacienda, offers more than 120 dishes every day. Hacienda Santa Martha has extensive grounds with play areas for kids, an artificial pond with pedal boats, and even movies for kids projected inside an old DC-4 airplane. Sample seven different kinds of mole, have meats and seafood grilled to your liking, and fill up on soups, salads and almost any Oaxacan dish you can imagine. It’s a great option for families and picky eaters because you can choose what looks tastiest - or try a bit of everything until you find something you like. Hacienda Santa Martha is open from 1:30 to 6:30 pm daily except Monday.

This gem right off Bourbon Street is close to the action but far enough (and insulated enough) to make you feel like you can get away from the frenetic pace of the city’s most famous avenue at a moment’s notice. Guest rooms are well-appointed and comfy, with plantation-shuttered windows, plush beds and sleek bathrooms. Plus, every guest gets a voucher for a welcome drink in the hotel’s smoke-free bar, the Bourbon O. Be sure to catch live music there on Friday nights, as well as bartender Cheryl Charming, whom a local magazine named Mixologist of the Year in 2014. Back at the hotel, the Roux on Orleans restaurant can satisfy breakfast, lunch and dinner desires, and a heated saltwater pool makes lazing about in a lounge chair all day very, very easy. But if you want to be the ultimage envy of Bourbon Street revelers, make sure to reserve a balcony suite; it features a porch overlooking all the boozy revelry below and lets you party above the action.

There may not be much to this tiny island in the French Polynesia but it’s big on history if you have any interest in Paul Gauguin and Jacques Brel. If you are looking for a secluded spot with little amenities, this is a perfect spot in paradise.

No photograph can capture this extraordinary art space created by mural artist Isaiah Zagar down at the quiet end of South Street in Philadelphia’s Center City—you have to see it to believe it. It’s also not easy to describe: an alternate universe? A magical mosaic environment? A creative outsider’s brilliant vision? A terrarium of otherworldly folk-art delights? Decide for yourself when you take a self-guided tour of this one-of-a-kind, ever-expanding project. The site includes an immersive outdoor-art installation crafted from found objects and handpainted tiles, as well as indoor galleries. The opening hours vary due to occasional public and private events; make sure to check the online calendar.

In warm-weather months, the Penn’s Landing waterfront area along the Delaware River is always busy with activity. On the Great Plaza there are ongoing free festivals, summer concerts, a movie series, and Fourth of July fireworks. Other attractions here include the RiverLink Ferry to New Jersey, the Independence Seaport Museum, and kayaks and swan boats available for rental. In winter, Penn’s Landing is host to one of Philadelphia‘s most spectacular outdoor ice rinks, the Blue Cross RiverRink. Historic ships, including the Moshulu, a beautiful 1904 four-masted steel sailing vessel, are moored at the waterfront. The Moshulu now features a popular restaurant on its deck, and the tall ship is dramatically illuminated at night.

Gennaro Castiello is passionate about Cetara and about the anchovies that provide income to the town. His stylish and simple restaurant is decorated with Vietri ceramics and wood, creating a chill, beachy vibe. A plate of fried anchovies accompanied by a cold flute of naturally processed prosecco makes for the perfect summer lunch. For something more substantial, order pasta dishes such as paccheri with zucchini and shavings of tuna bottarga, or a reimagined pasta alla genovese with tuna in place of beef, which transforms a hearty dish into something light and fresh. Castiello’s colatura di alici, a fermented anchovy sauce that has ancient Roman origins, just might be the very best in town. Make sure you bring home a bottle.