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Just beyond the western edge of Tucson, you’ll find these Hohokam petroglyphs in Saguaro National Park. No one knows precisely when they were carved into the rocks, but Hohokam settlements in the Sonoran desert date back almost two thousand years. We went on a short hike among the saguaro to end up on this hilltop with this pre-Columbian art—not your typical suburban stroll.

On the northern edge of Tucson, you can drive through a condensed version of western North America’s ecosystem in about half an hour. On the way up the Mount Lemmon Highway (also known as “Catalina Highway” or “Sky Island Scenic Byway”), you traverse almost all of the different life zones you would encounter if you were to actually drive from Mexico to Canada: starting with the saguaro-studded Sonoran desert, up through grassland, junipers and oaks, pines, and finally a mixed-conifer forest with stands of aspen. You begin at about 2500 ft. and end up at almost 9100 ft. above sea level (about 760 to 2770 meters). In the summer, especially, southern Arizonans love this road: “thirty miles, thirty degrees cooler,” as the saying goes. When it’s 105 degrees down in the city, it’s a perfect 75 up on the mountain. In the winter, you can go skiing in the southernmost ski resort in the U.S.

This isn’t your local Walgreens—the edgy glass-and-steel facade should tell you that. And while you can buy aspirin at its pharmacy or Le Figaro at its newsagent, Publicis is really about upmarket retail: Petrossian caviar, Acqua di Parma cologne, Harmon Kardon speakers, an 1,100 euro handbag from Jerome Dreyfuss. You can also pick up a fine cigar from its humidor or a fine Bordeaux from its wine cave. The two-story “drugstore” also houses a cinema, brasserie and two gourmet restaurants.

With two hiking trails ascending 1,280 feet to its peak, Camelback Mountain is a great option for nature-fiends who like a challenge. Both the Echo Canyon and Cholla trails exceed a mile in length and are accented with steep grades. Average hiking times range from 1.5 to 3 hours round-trip, so pack accordingly and bring enough water.

With its 16 craft beers selection and lengthy list of Arizona wine and signature cocktails, Historic Brewing Barrel and Bottle House is a can’t-miss. And we haven’t even mentioned the food yet: a Southwestern take on classic pub fare, with dishes such as fried avocado; a salad with black beans, corn nuts, and charred jalapeño vinaigrette; and a pulled-pork sandwich with homemade barbecue sauce. What’s especially unique about this spot is that it makes its own beer and wine; order the Love at First Flight for a sample of six wines or six beers, and enjoy them on the patio, if weather allows.

This is a great option for a day hike in the Grand Canyon. South Kaibab Trail is a well-maintained (but steep!) stretch of dirt with very little shade and a trailhead that’s accessible only by shuttle bus. No private vehicles are allowed in this portion of the park. It’s a scenic adventure through and through, but South Kaibab’s main destinations include Ooh-Aah Point (at the highest elevation of 6,660 feet), Cedar Ridge (good for novice hikers and late starters), and Skeleton Point (an unobstructed view of the Colorado River with steep switchbacks).

There are few places where you can better learn about the beauty and complexity of desert ecology than the Desert Botanical Garden, not far from downtown Phoenix. Check out the Desert Discovery Loop Trail for a look at local flora, go for a flashlight tour or cooking class (using plants found in the region, of course), or catch one of the musical performances that are part of the garden’s concert series. Make a point to visit the Desert Terrace Garden for the best views of the surrounding buttes and desert.

For anyone who believes that truly historic architecture doesn’t exist in the states, Mesa Verde National Park will make you think again. Still standing in the park are cliff dwellings built in 600 CE by the ancestral Pueblo people who once lived in the area. A transformative day trip, Mesa Verde is nearly two hours from Telluride but well worth the drive to see its 5,000 archeological sites, from Cliff Palace (a ranger will guide you on the hike up, which involves climbing ten-foot ladders) to Balcony House (which you’ll enter via a 12-foot tunnel).

Featuring mostly local wine and craft beer, South Rims Wine and Beer Garage is located on historic Route 66 in uptown Williams, Arizona. Here, you’ll find some of the best local white and red varietals on tap, such as Keeling Schaefer’s Viognier and Page Springs Cellar’s plum-and-pepper–forward Vino Del Barrio red blend, plus a deep selection of microbrews, including rich Koffee Kölsch from Huss Brewing Company in Tempe and a Hefeweizen courtesy of Oak Creek Brewing Company in Sedona. South Rims’ menu of food items, from the gourmet pretzel basket to the grilled sirloin, pair perfectly with the drink options. You’ll want to allow yourself plenty of time to sip at the bar, or enjoy a full meal on the sprawling outdoor courtyard.

Skimming along the Arizona border in the Vermilion Cliffs Wilderness, Buckskin Gulch is considered the longest slot canyon in the Southwest. After entering the intimate narrows of the canyon, the route continues on for about 15 miles until it reaches the Paria River. Along those 15 miles, the walls get as narrow as 10 feet and as tall as 500 feet above the canyon floor. While the route can be done in a day, many visitors take overnight gear and camp near the confluence before hiking out the next morning.

It’s a clever name to be sure, but the food at Kicks on Route 66 is even more enticing. With a focus on local and organic ingredients, the menu features “Arizona Kickers”—jalapeños stuffed with cheese, wrapped in crispy bacon, and topped with a sweet prickly pear sauce. The gourmet burgers are definitely a draw, but you’ll have a tough time choosing between them and other imaginative mains like the green chili chicken pot pie. (That flaky crust, though.) Sunday brunch at Kicks is popular with locals and travelers alike. Maybe it’s the buttermilk vanilla pancakes?

Located in historic downtown Williams, Arizona, just outside of Grand Canyon National Park, Red Raven Restaurant is cozy and casual with a brick exterior painted fire-engine red. The kitchen is small but sends out gourmet comfort food to diners seated in its high-ceilinged dining room. They tuck into dishes such as portabella and zucchini fries with a balsamic reduction sauce, broiled pork medallions topped with cilantro pesto and tempura-style broccolini, and a lamb and vegetable stew made with Guinness. Seating at this husband-and-wife–owned establishment is limited, so definitely call ahead.

Farming roots in Arizona’s third-largest city run deep, and the Fresh Foodie Trail highlights this history. Participants get a hands-on (and delicious) learning experience with pasta-making courses that use ancient grains, foraging excursions, and visits to some of the area’s best farmers markets, food trucks, and farm-to-table eateries. The farms surrounding Mesa—including those in neighboring towns like Gilbert and Queen Creek—produce a dazzling seasonal bounty: citrus in January, peaches in May, olives in October, and heirloom wheat during the winter months. The tour is an appetizing way to learn why your food choices matter.

Named after an artistic city in central Mexico, Sedona’s Tlaquepaque Arts and Crafts Village is one of the best outdoor shopping spots in Arizona. Sycamore-shaded fountain-filled courtyards and vine-covered colonnades are home to over forty galleries, boutiques, and restaurants. (The architecture may only be a few decades old, but this is one of the most well-done ‘pseudo-Mexico villages’ in the U.S.) The emphasis is on Southwest sculpture, blown-glass, painting, ceramics, textiles, and jewelry. If you want to take a break from your red-rock ramblings, this is the place.

Nature may have spent 12 million years creating the rock formation that is the centerpiece of this 1,300-acre Hilton Curio Collection resort in the foothills of the Sonoran Desert, but late-coming humans have done a commendable job of adding the finishing touches. Although the Boulders, with its casita accommodations blending into the landscape, its championship golf courses, and its upscale shops, is as luxurious as any resort in the Scottsdale area, it’s also where guests are most likely to feel they are truly in the desert. An early-morning walk along groomed paths, when the first rays of light are turning the landscape golden, is as likely to produce the sounds of woodpeckers or owls calling from their nests in saguaro cacti as it is the whack of a ball against club or racket.