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Even a Brussels native would be forgiven for thinking, at first glance, that the Dominican is a historic building. After all, the façade incorporates many of the features that existed when renowned 19^th-century French painter Jacques-Louis David lived at this address. And, inside, the site’s former incarnation as a 15^th-century Dominican monastery appears in such details as the courtyard colonnade and original stone floors in the serene Monastery Corridor. The soaring ceilings, oversized windows, and ornate ironwork of the Grand Lounge and its adjacent bar call to mind the grand cafés of early 20^th-century Europe, while rooms are adorned with vibrant paintings of classical subjects, like those by David and his contemporaries.

As historic as it all is, though, there’s no doubt that the Dominican is a modern hotel. The contemporary decor harmoniously complements its surroundings, and each of the 150 luxurious rooms has been individually designed. Many afford views of the impressive La Monnaie, the city’s opera house, located next door. The lounge is one of Brussels’ hottest spots for everything from power lunches to date nights, and the gym even has a private boxing room.

The Four Seasons Hotel Buenos Aires, which opened in 1992, is really two hotels in one. The more historic of the two is the three-story, Belle Epoque mansion, built in 1920 as a wedding gift from Félix de Álzaga Unzué, a member of a prominent local family, for his bride, Elena Peña. There are mansard ceilings and toile de Jouy wall panels, and many suites are housed here. The other building is a modern 12-floor tower, which holds the bulk of the rooms. These feature double-glass windows, private bars, and armoires with HD TVs. Every cushy amenity expected of a Four Seasons property is found in both styles.

In 2013, most of the common spaces underwent a $49 million renovation, completely overhauling the lobby and the spa, and adding two new restaurants. There’s still the Roman-style outdoor heated pool overlooking La Mansión, but to complement it, more of the outdoors has been worked into the hotel: lavishly landscaped gardens, a rooftop garden, and a glass-enclosed asado-style restaurant that can be opened up to fresh air.

Up-and-coming starlets in the 1920s and ‘30s would have stayed at the Crescent. When the palm tree–lined art deco building opened in 1927, it was as lodgings for the budding actresses who’d just signed studio contracts and moved out to L.A. for their big breaks. They, too, sipped cocktails (after Prohibition ended, of course) and listened to jazz (probably not by a live band, though) in the intimate lounge and on the breezy terrace. It’s even just possible there was saltwater taffy at the front desk and a library stocked with an impressive collection of classic and contemporary literature and nonfiction. However, the walls might not have been adorned with paintings and photographs by some of the area’s top artists, and there definitely wasn’t 24-hour room service or iPod docks.

After the studios moved on, and luxury designer shops and trendy restaurants moved in, the Crescent turned into a cozy, quirky boutique hotel known for its prime location, affordable rates, and bend-over-backward service. These things won’t change.

A detour to the centrally located yet way-off-the-tourist-track neighborhood known as Buenavista leads to one of Mexico City’s most dazzling 21st-century landmarks, the Biblioteca Vasconcelos, a gorgeous public library. The structure, by Alberto Kalach and Juan Palomar, has the public entering a pyramid-style form, on an almost subterranean level, that opens up, cathedral-like, into a soaring space lined on either side by cantilevered book stacks that float nobly above it all. Dramatic artworks contribute to the overall temple-of-knowledge feeling that is, in fact, quite moving. More beautiful yet could be just how busy the library is, filled with eager students and bookworm families alongside (no joke) groups of teens always practicing pop-music dance routines in the library’s lateral gardens.

Life reflects art? The Reina Sofia museum in Madrid is home to Picasso’s famous Guernica, and many works by other Spanish artists, including Miro and Dali. A fabulous place to discover the art, artists, and ideas of the 20th century.

From the first “woof” of welcome from the resident Canine Ambassador, guests feel a part of this storied hotel’s century-plus history. Located in the Back Bay, not far from Beacon Hill, Newberry Street, and the Freedom Trail, the landmarked Fairmont Copley Plaza houses 383 comfortable guest rooms, each featuring modern-elegant decor as well as signature pillow top mattresses, 46-inch TVs, and coffee makers. Snag a room on the Fairmont Gold concierge floor for extras like private check-in, complimentary Wi-Fi, and use of a snack-stocked lounge.

Sweeping views of the city can be enjoyed from the 3,000-square-foot rooftop gym (which is lined with floor-to-ceiling windows) and the sophisticated event spaces (which, decorated with chandeliers and ornate furnishings, are a top pick of Boston brides). The hotel’s convenient location makes it easy to sample the city’s great eats, but you’ll do well if you stay in, too, thanks to the handcrafted cocktails and farm-to-table dishes served at the on-site OAK Long Bar + Kitchen.

Sunset Monalisa is one of the most romantic restaurants in the world. Its views of Cabo San Lucas Bay and the arch at Land’s End are spectacular any time of day but particularly at sunset, when the sky turns vibrant shades of red, yellow, and purple. Love is definitely in the air here: Servers report at least one engagement per week, and it’s a favorite wedding venue. The multitiered cliffside restaurant features a Taittinger Terrace Oyster and Champagne Bar, as well as an exceptional Mediterranean menu from chef Paolo della Corte, who trained in Michelin-starred kitchens. Navigate the à la carte options independently or opt for the prix fixe or tasting menus.

Make it Right was founded by Brad Pitt in 2007 and they build ‘healthy homes, buildings and communities for people in need’, in beautiful fashion. They believe that ‘energy efficient, well-designed homes should be affordable and available for everyone.’ . See what all they are doing and have done in New Orleans and elsewhere and be inspired.

San Francisco-based selvedge denim shop Self Edge has hung a shingle south of the border, becoming one of the first retail boutiques to open on the Flora Farms property in San José del Cabo. Aiming to be not just a store, but an experience, Self Edge is best-known for its well-tailored denim jeans. At the Baja shop, guests can also find Japanese-designed cabana shirts and resort wear, not available elsewhere in Mexico. The owners are also collaborating with local artists to make indigo-dyed sandals that will be exclusive to the store. Other unique jewelry and accessories are also on offer.

A Madrid-based gallery that showcases some of Guadalajara’s best artists, Travesía Cuatro serves as a bridge between the European and Latin American art scenes. Perhaps more impressive than the work on display, however, is the gallery’s setting inside Casa Franco, a 1929 Mediterranean-style home designed by the father of Mexican modernist architecture, Luis Barragán. The landmarked space has the casual feel of a home—that just happens to have a fantastic art collection.

As tourists gaze up at Michelangelo’s dome in St. Peter’s Basilica, many have no idea that one of Vatican City’s most compelling historic sites is directly beneath their feet: the Vatican Necropolis, also known as the scavi (excavations). This multilevel subterranean area tells the story of Vatican Hill’s ancient Roman suburban beginnings. Take a walk through a 1st-century C.E. necropolis (once a cemetery and mausoleum), 5th-century Christian burial area, the Vatican grottoes, and the original 4th-century church foundation walls.

La Virgen de Guadalupe-Our Lady of Guadalupe–is revered by Mexicans, and her image is ubiquitous, found in every form imaginable, from traditional statues to bumper stickers. She also lends her name to any number of businesses and buildings, including the Basilica to which faithful flock–many on their knees or carrying crosses–each December 12. The arrival of the pilgrims is a sight to behold, but so is the basilica, an architectural marvel, which you can visit any time of the year. Completed in 1976, the present basilica is not the first one to have sat on this site; an older one, which needed to be replaced because it was sinking, remains on the grounds and is open to the public after renovation and rehabilitation. The principal architect, Pedro Ramiréz Vázquez, who died in 2013, is responsible for some of the most compelling modern buildings in Mexico City, including Estadio Azteca and the National Anthropology Museum, as well as a number of buildings throughout the country and abroad.

There are few better places from which to enjoy river views and sunsets than the Ponte Vecchio, built in 1345. Spanning the Arno’s narrowest point, this is the only bridge to have survived the German bombing of the city in 1944. There have always been shops on the bridge; the original butchers and grocers were replaced by sweeter-smelling gold and silversmiths in 1593. Sitting right in the middle is a bust of Benvenuto Cellini (1500-1571), the most famous goldsmith of them all.

Old San Juan may look, at first glance, like a few other charming cities built during the height of Spanish colonialism—Havana or Santo Domingo, for example—but what sets it apart is the extent to which its architectural infrastructure from that era remains visible. It’s the only city that has its original colonial wall almost entirely intact, and both of its principal forts are in excellent condition, remain accessible to the public, and offer panoramic views of the Atlantic Ocean (so bring your camera). Both El Morro and Fuerte San Cristobal are run by the National Park Service; guided tours will leave you with greater knowledge about the era, as well as the forts’ construction and their role in Puerto Rican history. (There are other, smaller forts in and around the capital, next to the Caribe Hilton, and in Luís Muñoz Rivera Park, plus Fort San Juan de la Crúz in the nearby town of Cataño.)

A 1,200-acre green space filled with museums, theaters, and gardens, Balboa Park is the center of art and culture in San Diego. It’s also one of the city’s most historic sites, built for the Panama–California exhibition in 1915. While the museums are definitely worth seeing, there are also a number of free attractions, including the photogenic Botanical Building, which houses more than 2,100 plants (including Venus flytraps); the Desert Garden, filled with succulents from around the world; and a sculpture court with works by Miró and Rodin. For one of the area’s best views, purchase a timed ticket to climb the California Tower in the Museum of Man. The ornate structure reopened to the public in 2015 after being closed for nearly 80 years and features a spiral staircase to the eighth floor, where you can catch a glimpse of the Cuyamaca Mountains, the Cabrillo Bridge, and even Mexico’s Coronado Islands.