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The Inca Trail is perhaps the most famous trek in Peru. This is the road to Machu Picchu, an ancient route that leads from the Sacred Valley into the heart of the Andes. You must obtain a permit and hire an official guide in order to hike the Inca Trail proper. There are plenty of tour operators in Cusco that offer trips up to Machu Picchu, so you should definitely look at reviews before you choose. For better or for worse, the tours are all-inclusive. The local tour operators employ porters to carry your packs and set up a camp. A team of local chefs will prepare three meals a day, and many hikers come back raving about the delicious meals. Keep in mind that the trek can be tough, especially in the first few days. The trail is often narrow, and it flirts with formidable heights. The mountains in this part of the Andes can rise well over 13,000 feet, and many hikers find themselves suffering from altitude sickness. Make sure to take a few days (in Cusco or the Sacred Valley) to acclimatize before you begin the journey. Finally: make sure to plan ahead! The Peruvian government limits trail access to 500 people per day, including porters. This regulation protects the local ecosystem and the delicate ruins, and it ensures that the trail won’t be too crowded. However, it also means that permits for the peak summer season sell out months in advance. If you aren’t able to get a permit for the classic Inca Trail, never fear: there are various other trails that lead to Machu Picchu.

Chef Edgar Nuñez staged at some of the world’s top restaurants, including Noma and the now-shuttered el Bulli, before returning to Mexico to hang his own culinary shingle. The lessons he absorbed during his training have been put to good use, earning him the #27 spot on Latin America’s 50 Best Restaurants list. The menu at Sud 777 is divided into sections such as “River and Sea,” “Heaven and Earth,” and “Mexican Coasts.” The domestically sourced ingredients reflect the clean, fresh flavors of Mexican produce and seafood. Look, too, for a restaurant inside the restaurant: kokeshi is a Japanese-inspired spot with an extensive sushi menu and plenty of sake.

Elevate the normally mundane experience of shopping for medicine-cabinet basics like soap and toothpaste with a visit to one of the oldest pharmacies in the world. In this 13th-century chapel with early Renaissance frescoes, Gothic carved wooden cabinets, and crystal chandeliers, most items are still crafted according to formulas originally created by Dominican monks. A small museum displays equipment once used to make Santa Maria Novella products, as well as a collection of beautifully painted ceramic jars that held the herbs and powders. Linger a little longer in this fragrant world by ordering a pot of herbal tea or a small glass of one of the historic liqueurs in the tearoom.

The system of canals and chinampas (cultivated artificial islands fashioned from the area’s swampy soils) that has survived in the far-south neighborhood known as Xochilmilco once stretched all the way to the Centro. To this day, the community is known for its plant nurseries and vegetable gardens. These ancient landscapes now contribute to what has become one of the most singular pleasure gardens in the world, where visitors hire “gondoliers” to propel boats known as trajineras as they sail these channels in the company of floating mariachis and food vendors, partying teens, and extended families out for a picnic lunch. Since a tour is usually a four-hour-plus investment (it flies by), ask your oarsman to take you to Xochimilco’s more-rural precincts, where you’ll enjoy marvelous quiet, far from the madding crowd, in the company of cranes, curs, and picturesque cornfields.

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