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When Cardinal Ippolito d’Este narrowly lost the Papal election, he assuaged his frustrations by embellishing a spectacular villa in Tivoli, a village in the hills east of Rome. The villa itself was brilliantly outfitted in 16th century frescoes, while the gardens were the highest achievement of hydraulic engineering for the age.

During the late 19th and most of the 20th centuries, the Testaccio district hummed with activity from the sprawling slaughterhouse. Thought animal slaughter was moved away from Testaccio in 1975, most of the building has been preserved. In recent decades, areas have been slowly transformed for new functions. The place houses a contemporary art exhibition space called the MACRO, a university campus, and even an organic supermarket (open Tuesday to Sunday).

One of Rome‘s best bakeries and among the city’s most historic institutions, Antico Forno Roscioli is a family-run business. Depending on the time of day, you might find patriarch Marco or his son Pierluigi hard at work. There are a variety of baked goods, including pizza by the slice, flatbreads, loaves, and sweets. The pizza bianca (flatbread brushed with olive oil) and pizza rossa (crispy flatbread dressed with light tomato sauce) are sensational, and the pane di Lariano (crusty sourdough bread) is the best in Rome. Be sure to check out their wine bar/restaurant/gourmet food shop—called, simply, Roscioli—nearby.

by Fabrizia Lanza Within the Palace of the Normans, there’s a chapel of the kings. “It’s sumptuous,” Fabrizia says, “all covered with mosaics. It’s like getting inside a golden box of jewelry.” Piazza del Parlamento 1 This story appeared in the January/February 2011 issue.

A favorite with the locals, especially government workers at lunch, this place is always packed, and with good reason. For $10 or less for an authentic and delicious lunch special (with a drink), this place is a steal. Try the asopao de camarones (shrimp soup with vegetables and saffron rice) with a side of tostones (mashed and fried plantains) and ask for the local hot sauce, pique, a smoking mixture of habañero peppers, black peppercorns, spices, and oil and vinegar. Service is reasonably fast and the waiters are friendly, but certain times of day (12-1pm weekdays, and 6-8pm on weekends) can be impossible for getting a table. Reserve ahead, or be prepared to wait in the plaza nearby.

Founded in 1913, this famous botanical garden was the first in the world dedicated to its country’s own flora. The spectacular, 90-acre plant haven forms part of a nature reserve that borders Table Mountain National Park. Besides numerous gardens and forests—some of which you can traverse on high via the futuristic Boomslang (Tree Snake) walkway—Kirstenbosch has a greenhouse, a restaurant run by the popular Moyo group, and a nursery for green thumbs who want to take a piece of the garden home with them. Spend five minutes here and you’ll realize why Kirstenbosch’s displays at the Chelsea Flower Show in London often win gold.

Regulars at this Little Italy joint (and there are lots of regulars) flock here more for the friendly atmosphere and the cheap drinks than for the two bowling lanes that gave it its name (“quilles” is “bowling” in French). Games do happen though, usually more as the night goes on, unless it’s one of the nights when a band uses the lanes as a stage. The drinks are nothing special except that most moments in this down-home haven end up being special, and they go wonderfully with the vegetarian burritos made on the spot. Take a spot at the bar to keep the pints coming, or find a nook in the back or in the turquoise-painted side room to wile away the hours.

Most people have heard of the Kuekenhof tulip gardens of the Netherlands, but few know about the even larger Arcen Gardens in the south of the country, near Venlo. This massive, 42 hectare, garden complex is on the grounds of the 17th century Arcen Castle. The gardens begin in a traditional formal style, with roses, hedges and statuary. But it doesn’t end there. As you wander through, you encounter gardens designed to resemble Japan, Italy, Thailand and more. There are woodland gardens and tropical gardens (inside an enormous greenhouse). There is a small on-site zoo featuring ring-tailed lemurs, plenty of children’s activities, mini-golf and a large cafeteria. In fact, you could easily spend an entire day and still not see everything. Arcen opens for the 2013 season on April 26th.

Bideluze hits all the right notes. There’s nothing artisan or hoity-toity about it. Just a good, comfortable Irish pub style vibe, with pintxos that are big enough to qualify as sandwiches and a kitchen open all day long. Mornings in Bideluze are the best. The buzzy, warm ambience is the best to enjoy a big cup of Colacao, Spanish hot chocolate, which they make the RIGHT way here. The interior of the mug is coated with the paste before being filled with hot milk and served with four Maria cookies. Perfection.

Café de La Concha is a perfectly satisfactory café for breakfast, lunch, or dinner. However, what it does really well is sit smack dab in the middle of La Concha Beach. This means there is no place more picturesque to take a morning coffee than its terrace, which has views of the bay and the surrounding mountains. If you are in town for Semana Grande, it’s the spot to be for fireworks watching, just make sure to reserve a spot for dinner.

In 1967, Tassajara (already a storied hot springs resort) became the first Zen monastery outside Japan. Run by the San Francisco Zen Center, the monastery is open to the public from May through September and closed the rest of the year for monastic study. The only vehicle access to Tassajara is via the 14-mile dirt road that starts in Carmel Valley. Those without four-wheel drive should arrange for shuttle pick-up.

Even with all the noted thinkers, artists, politicians, and powerful families who’ve called Florence home, Leonardo da Vinci is arguably the city’s most famous son. This homage focuses less on his artwork and more on Da Vinci’s forward-thinking inventions and theories. The exhibits are separated into five themes, with each including models based on Da Vinci’s instructions. The Earth section includes pieces like printing machines and an oil press; Water has hydraulic saws and water floats; Fire boasts military artillery inspired by the Atlantic Codex; Air has Da Vinci’s parachute, flying machine, and “winged man” paragliding prototype; and Mechanisms includes items based on Da Vinci’s codexes, to demonstrate their principles. Most items are hands-off, but kids will have fun learning how to operate the rotating crane and other models. Most of the pieces are made of wood, so you really get a feel for their bones—and for Da Vinci’s genius.

The cathedral, usually called the Duomo, is Florence’s most recognizable building. You are able to catch glimpses of its magnificent red-tiled cupola from just about anywhere in the city center. Construction on the church complex began in 1296 and the work—Brunelleschi’s dome and his Baptistery, and Giotto’s bell tower—was completed in 1426. The interior of this architectural is reserved in contrast with the exterior’s marble Gothic facade and its green, pink, and white stripes. Climb the 463 steps up into the dome for a close-up look at Giorgio Vasari’s fresco, The Last Judgment, and a bird’s-eye view of the city.

A short drive outside the town of San Pedro de Atacama, Tierra Atacama has wonderful views of fields and Volvano Licancabur. The hotel is part of the Tierra hotel group owned by the Chilean-American Purcell family (who also own Tierra Patagonia, Tierra Chiloé, and Ski Portillo). The property originally served as a cattle corral, but Chilean landscape artist Teresa Moller has transformed the grounds, preserving the ancient algarrobo and chañar trees and restoring the adobe walls.

The bedrooms are decorated in natural colors, with local touches like ceramics marching along the sills of the extra-large windows. Animal-skin rugs and alpaca throws provide a touch of warmth for the cool desert nights. You can see the incredible silhouette of Volcano Licancabur from all the rooms, but the Poniente rooms are slightly larger and have better views. There is a friendly communal vibe at the hotel, and upon arrival guests meet with the head guide in the main lounge to choose from the range of group activities on offer each day.

Dating to 1521, the Cathedral of San Juan Bautista isn’t just one of the oldest buildings in San Juan—it’s the second-oldest cathedral in all of the Americas. Go inside to see the tomb of Spanish explorer Ponce de León, who founded the first settlement on Puerto Rico and in 1509 was named the island’s first governor. The remains of St. Pio, a Roman martyr, can also be seen in the cathedral—the saint’s mummy has been displayed here in a glass box since 1862.