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The Palatine Hill was home to an early Roman settlement and had major significance for the city’s history. Legend states that Romulus founded Rome on that hill in 753 B.C.E., and Romans even maintained a cult site sacred to the founding father for about 1,000 years. When the emperors rose to power, they chose the Palatine as the location for their sprawling villas and built enormous marble-clad structures to showcase their wealth and power. Today, the ruins of their majestic estates rise above the Forum and Circus Maximus, reminders of the grand imperial past. A visit is included in the price of a ticket to the Forum or Colosseum.

This enclave on upper Boulevard Saint-Laurent in Little Italy emanates style from the front window on, with a quirky and impeccable approach to layout. Its rich wooden tables and modernist shelves are rife with unique, collectible objects and everyday useful things. Some are wearable, like silk scarves, merino wool sweaters and designer galoshes, while others exist to embellish living spaces, like beautiful metal bowls and hand-painted birch branches that serve as sculptures. There are even edible things, like artisanal lemonade syrup and fancy teas. The focus is on locally made goods with a smattering of international purveyors too, who fit within the store’s general earthy-chic aesthetic.

Maria e Susanna Sent has several shops where they sell their glass jewelry, the cutest one of them all just off the Ponte San Moisè in San Marco. This boutique is about as big as a broom closet, and that is certainly part of its charm. The real impact, though, comes from the jewelry this artistic duo started creating on the island of Murano back in 1993. Their line of mostly necklaces and bracelets is made in a unique process that creates murrine and filigree glass and plates in glass fusion. They also have shops in Murano and in Dorsoduro near the Peggy Guggenheim Museum.

Don’t let your eyes fool you. Villa Panza is a not just a gorgeous 18th-century estate. The villa and grounds host the spectacular Panza Collection, an amazing grouping of art from the 1960s through 1980s, with particular attention to American artists. The individual pieces (paintings, sculptures, drawings) are incredible but what makes the collection are the site-specific installations from artists such as Dan Flavin.

While exploring Burano, break for a fabulous seafood lunch at Al Gato Nero. The “black cat” restaurant is the creation of Ruggero Bovo, who has been cooking up some of the tastiest fresh fish and seafood here since 1965. “I love the fish of the Venetian lagoon and the Adriatic Coast, the raw material which has fed my island for generations and which I still have the fortune of getting fresh every day,” Bovo says. Fish and seafood are the star attractions on both the appetizer and main menu selections, but there are also options for vegetarians and carnivores. The pasta here is homemade, as are the delicious desserts.

Isola is Milan‘s sleeper neighborhood because of its great location, hip shops and local vibe. It is also a great area to hang out in because, well, it feels like a neighborhood. Weekend street markets, clever graffiti, cute boutiques, artisanal shops and great bars. Add in there a strong sense of AC Milan fans and lots of people to meet, you’ve got your weekend.

Located in a former rail services warehouse, Hangar Bicocca is a contemporary art space for site-specific projects funded by tire giant Pirelli. The space is more like a contemporary art concept that extends from the boards of its brick structure. The art gallery offers bicycle tours of the Bicocca area, as part of the “Bicocca Project,” a neighborhood reclamation project intent on showcasing the former industrial zone as vibrant neighborhood and equally vibrant arts scene.

Leoncavallo is both a cultural center and a concept. The buildings lining the run-down road are covered in amazing art by epic artists and upcoming writers. During the day, you’ll find photographers documenting the work or shooting for fashion mags and street art aficionados snapping the latest work. The building inside also gets painted by artists, local and international. Best way to get a peek is to visit for a project or concert.

Since first reading about Capri as a teenager, I had dreamed about a shop like this. Crammed with hundreds of colorful tunics and beach coverups, Antica Sartoria makes it easy to leave with a bag stuffed full of gifts for oneself and friends back home. The inexpensive resort wear makes liberal use of polka-dots, paisleys, and ornate designs. Not a shop for wallflowers. There’s another outlet in Positano.

If you are in the San Lorenzo market area around lunchtime, this little enoteca (wine bar) with its old-fashioned, wood-paneled interior is a good place to stop off for a glass of wine and a sandwich or crostino. It’s usually standing room only, but the choice of wines is great and it’s got a buzzy, local feel to it. There’s a great, well-priced selection of wines to go too.

In spite of featuring in all the guide books, this Santo Spirito favourite has a loyal local following, and the place is always packed out with a mix of tourists and Florentines who line up for good value, homecooked food. I would recommend choosing the Tuscan specialities such as the hearty minestrone with rice and black cabbage and the oven-roast guinea fowl (‘faraona’). Homemade apple cake is a great way to finish.

When Cardinal Ippolito d’Este narrowly lost the Papal election, he assuaged his frustrations by embellishing a spectacular villa in Tivoli, a village in the hills east of Rome. The villa itself was brilliantly outfitted in 16th century frescoes, while the gardens were the highest achievement of hydraulic engineering for the age.

During the late 19th and most of the 20th centuries, the Testaccio district hummed with activity from the sprawling slaughterhouse. Thought animal slaughter was moved away from Testaccio in 1975, most of the building has been preserved. In recent decades, areas have been slowly transformed for new functions. The place houses a contemporary art exhibition space called the MACRO, a university campus, and even an organic supermarket (open Tuesday to Sunday).

Burano is quaint and touristy in the same breath. Some might argue that there is not much to see beyond the multi-colored buildings. But there is definitely something worth eating - sardines! Sit in the sun at Riva Rosa and enjoy along with seafood risotto and spaghetti alle vongole.

One of Rome‘s best bakeries and among the city’s most historic institutions, Antico Forno Roscioli is a family-run business. Depending on the time of day, you might find patriarch Marco or his son Pierluigi hard at work. There are a variety of baked goods, including pizza by the slice, flatbreads, loaves, and sweets. The pizza bianca (flatbread brushed with olive oil) and pizza rossa (crispy flatbread dressed with light tomato sauce) are sensational, and the pane di Lariano (crusty sourdough bread) is the best in Rome. Be sure to check out their wine bar/restaurant/gourmet food shop—called, simply, Roscioli—nearby.