Mendoza was originally inhabited by the indigenous Huarpe tribe, who created a complex irrigation system to bring water from the mountains to the desert landscape. In the 16th century, Mendoza was colonized by the Spanish, and in more modern times the city experienced heavy European immigration (predominantly Italians), resulting in a strong Catholic influence. Today, wine has put Mendoza on the international map, attracting travelers from around the world to enjoy this charming, slow-paced city.

La Fiesta Nacional de la Vendimia is Mendoza's largest festival, which celebrates the wine harvest. Beginning in January, the city comes alive with regional folkloric events that culminate in March with music, dancing, parades, crowning of the Queen of the Vendimia, and of course, winetasting. El Carrusel and La Via Blanca parades lead up to the night’s central act in General San Martín Park’s amphitheater, attracting over 40,000 spectators. It’s a world-renowned event not to be missed. During Easter week, the Classical Music Festival with over 40 concerts takes place in select wineries.