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Built in 1525 as the family home of Doge Andrea Gritti, this antique-stocked palazzo has rooms with mosaic floors, hand-painted furniture, and panoramic views of the Grand Canal. Murano glass chandeliers and sconces light up the hotel that Ernest Hemingway called “the best hotel in a city of great hotels.”

Hotel Gritti Palace, Campo Santa Maria del Giglio, Venice, 39/041-794611. From $519. This story appeared in the July/August 2011 issue.

The Piazza Della Repubblica was the place to be in Florence in the evenings. Tourists and locals alike dined at the restaurants lining the square, student groups gathered, families enjoyed the Carousel, and gypsies and other migrants tried to sell everything from silk scarves to toys..right up until the police arrived and they all magically disappeared.

I fell in love. I fell in love with the town of Marfa. Safari tents. Stand alone bathtubs. Vintage trailers. Twinkle lights. Hammocks. An off the beaten path campground takes you to another world. You can choose to stay in one of their hip vintage trailers, eco-friendly safari tents, or in one of two teepees. The place fills up so all that was left was the safari tent. I felt like I was in a part of Moonrise Kingdom. It takes up 18 acres in Marfa, Texas and it has a place where they host live music, a communal kitchen, a shaded nook full of swinging hammocks, a community lounge and a small little shop filled with unique finds. It’s a place that just steals your heart and makes you wonder when you can come back.

After Vltava River floods brought great devastation to this gritty neighborhood and old port, a great change and rebirth began, and new businesses, stores and restaurants began moving in to old factory spaces and art nouveau buildings near the main square and church. Now Karlin is a foodie hotspot and a gentrifying neighborhood. Located across the river from Holešovice, to the east of the historic Old Town, Karlin is home to Veltlin wine bar, which focuses on natural wines from the former Austro-Hungarian Empire; Tea Mountain, a gorgeous tea room; Můj Šálek Coffee; and Eska, a restaurant-bakery serving neo-Nordic-inspired Czech cuisine in a modern industrial setting.

As you approach Lake Naivasha from Nairobi, the one-lane, potholed road rises and you are suddenly treated to a truly awesome view of the Great Rift Valley stretching out to the horizon. Shimmering within that vista is Lake Naivasha, a popular weekend destination for Nairobians. The lake itself is beautiful in a prehistoric-looking way, with wispy, jagged trees jutting up from the water and hippos bathing in the midday sun. Along the boggy shoreline, before the water lilies and tropical grasses give way to the open water, it’s easy to imagine ancient creatures wriggling their way up onto land and eventually evolving into the first hominids. While in the area, explore Hell’s Gate National Park and its gigantic gorge, take a boat trip on the lake in search of hippos, and get your fill of the freshly made pizzas at Camp Carnelley’s.

This archipelago off the coast of La Paz (which takes the name of the main island) is a protected UNESCO Biosphere Reserve. While the islands are uninhabited by humans save for a small fishing camp made of temporary structures, they’re home to a great variety of flora and fauna. In addition to dolphins, frigate birds, and ring-tailed cats, you’ll find the only known black jackrabbit population in the world. Celebrated eco-friendly activities company Cabo Expeditions leads daylong archipelago tours that include exploring the mesmerizing volcanic landscape, a ceviche lunch, and an opportunity to swim on Ensenada Grande Beach—often cited as one of the world’s most beautiful—plus guided snorkeling with the incredibly playful pups at the Los Islotes sea lion colony.

While the name of this cape sounds scary, it apparently stems from the Nordic word for “turning point,” as Cape Wrath marks the most northwesterly tip of the Scottish mainland. It was here that Viking warships would turn south, heading for conquered lands in the Hebrides. Today, it’s simply a gorgeous place to visit, with spectacular views of the coastline, ocean, and surrounding moorland from the Clo Mor cliffs—the highest on the Scottish mainland, rising some 620 feet from the shore.

Since the cape is so remote, access is challenging—there’s only one road and it’s separated from the main network by the Kyle of Durness, plus it’s closed to public vehicles. The only way to get here without hiking over moorland is to take the Cape Wrath Ferry across the Kyle, or the Cape Wrath Minibus, which offers a tour along the 11-mile stretch of road leading to the cliffs.

Opened in 1997, Jumeirah Beach Hotel is one of Dubai’s first modern resorts. The broad, wave-shaped tower sits next to a white-sand beach with a full flight of water sports, and it gets year-round traffic including many sun-seeking Russian package tourists and British families. Despite a capacity of more than 1,200 guests, the hotel has enough pools and restaurants to absorb the crowds. The guest rooms are still some of Dubai’s largest (that’s saying a lot), and the hotel is a convenient 20-minute taxi or free shuttle ride to the Gold Souk on Dubai Creek, or to the Mall of the Emirates, site of Dubai’s famous indoor ski slope. Kids will want to maximize their time at the Wild Wadi water park just up the beach, where Jumeirah Beach Hotel guests enjoy free entrance. Couples migrate to the 24th-floor Uptown Bar patio for cocktails and breezy views of the Persian Gulf and the lights of Dubai’s iconic skyscrapers, including the Burj al Arab and Burj Khalifa.

Located in downtown Fort Myers’ River District, this special facility is the place to learn about native Floridian butterfly species. During visits, guests can also observe how the critters are raised and released into the wild. The center focuses on butterflies from Southwest Florida and even teaches how to create an attractive environment for the species in your own backyard. Plan your visit around the butterfly release, which happens every day at 10:30 a.m., and be sure to stop by the onsite gift shop for unique souvenirs.

It’s not just Restaurant le 3842’s elevation that will make you lose your breath. Known as one of Europe’s highest restaurants (3,842 meters above sea level), this remarkable spot provides panoramic views of snow-dipped Alpine peaks that you can almost reach out and touch. Somehow built onto the side of Aiguille du Midi and only accessible via the cable car, this remarkable feat of engineering seems more like the dining place of Gandalf the Grey than a quality French restaurant. Once you’ve dragged yourself from the viewing platform, head inside to dine on locally sourced fare including cured meats, cheese, and Savoie rump steak.

There is a staggering amount of artwork on display here. It is said that if you stood at each piece for just one minute, it would take you four years to see everything. Created by Pope Julius II in the early 16th century, the museums have expanded over the past 500 years to their current size of more than 12 acres! Highlights include the Borgia Apartments, the Raphael Rooms, the Gallery of Maps, and of course, the sublime Sistine Chapel.

Among the 20 percent of Aruba that’s protected land, Arikok National Park boasts lava fields, limestone terrain, and a small beach, all crisscrossed with picturesque hiking trails. Paths lead to gold mine ruins, former plantations, and paintings by the island’s native Arawak people, making for an exciting place to visit. Explore the park by mountain bike, horseback, or car, or take a free walking tour with a park ranger (reservations must be made at least 24 hours in advance). You’re likely to see snakes, owls, bats, lizards, and myriad birds, as well as goats and the local donkeys.

Don’t let Portland’s low-key, outdoorsy-hipster vibe fool you: the Heathman Hotel is as grown-up and refined as they come. Opened in 1927 as an expansion of one of the city’s grande dame hotels, the Heathman continues to set the standard for classic luxury in the City of Roses. Rather than rest on its laurels, though, the hotel has consistently upped the ante, collecting a museum-worthy array of modern art (including a handful of Warhols alongside works by acclaimed local artists), boasting one of the most impressive collections of autographed books in the world, and offering guests a choice of mattress in the sumptuous rooms. Indeed, so famously decadent and romantic is the Heathman, with its award-winning restaurant and almost-nightly live jazz in the bar, that it was used as the setting for several of the rendezvous in E.L. James’ infamous Fifty Shades of Grey—although, for most guests, the original crystal chandeliers and marble fireplaces inspire magic enough.

An oasis so idyllic, you might first think it’s a mirage, Hotel Fellah is an eight-acre retreat that fuses Moroccan culture with a hipster design aesthetic and a farm-to-table ethos. Locals, artists in residence, and guests mingle in the art center and library, and at the educational farm, kids groom donkeys, milk goats or collect eggs that are sold in neighboring villages. The small café opposite the swimming pool is run by Touco, a resident of nearby Tassoultante village. Don’t miss his tagine, or—even better—pick ingredients from the garden and ask him to show you how to make it.

The city’s most famous snowbird, architect Frank Lloyd Wright, spent winters at his home and architecture school in the Sonoran Desert. Taliesin West brings the horizontal lines and organic materials of Prairie School design to the desert landscape in low, skylighted buildings. Behind-the-scenes tours visit the pop-up structures that students have designed as living spaces amid the barrel cactus and paloverde trees.