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Swim the Caribbean Sea. Hike through Tayrona National Park. Trek to Ciudad Perdida, the Lost City. Take in Colombian coffee culture in the Coffee Triangle. Or just wander the streets of one of Colombia’s cities to take in enough art and culture to keep you talking about this stellar South American country for the rest of your life.

Whether you want to stay by the Pacific coast, on the Caribbean side, or in the capital city, Panama offers visitors a wide range of accommodations, from beach resorts to rainforest lodgings to urban hotels. Relax by the beach on Isla Boca Brava, bird-watch from your bedroom in Soberanía National Park, or spend the night in trendy Casco Viejo.

Housed in everything from a 17th-century palazzo to an ancient fortress to a 350-year-old farmhouse, Malta’s best hotels blend history with modern luxury. Whether you want a spacious room with views of the Grand Harbour, a great location within walking distance of major sites, or a rooftop pool to relax by after exploring the capital city, you’ll find it all, along with loads of traditional charm, in this fascinating island nation.

The give and take of a 20-year friendship.

From the national brands at Faneuil Hall and downtown Boston to the boutiques of Newbury Street, Charles Street, and the South End, the city’s shopping areas offer a lot of something for everyone. If you’re craving the best of Boston’s small producers of good eats, head straight to Boston Public Market. In Cambridge, Harvard Square’s hidden gems lean more bookish and, at times, more counterculture.

Three days in Tokyo offers just enough time to give you a taste of the city’s range. Explore the Nezu Museum, Mori Art Museum, Tokyo National Museum, and the Meiji Shrine to immerse yourself in Japanese history, art, and culture. Start one of your days early with a tuna auction at the Toyosu Market--formerly the Tsukiji Fish Market--before heading off do some shopping, head to the top of Roppongi Hills for a view of the city, or to taste your way around the world--without leaving Tokyo.

There are plenty of ways to have a perfect weekend in Singapore. For a small place, it packs a mighty punch of delight. For first timers, a taste of the outdoors, a splash of shopping, and more than a few hearty servings of food will leave you craving more. Browse the National Gallery Singapore. Explore the Gardens by the Bay. Sip a sundowner at one of the stunning rooftop bars. And eat eat eat. (The food is so incredibly good.) Make your way outside of the city center to see the world-famous Singapore Zoo.

Cactus and cowboys are just the beginning here. World-class spa-resorts dot the foothills of this desert city; the mountain ranges are topped with observatories and evergreen forests. A research university and an air force base add variety to the Anglo/Mexican mix. Mild winters and eternal sunshine draw runners and cyclists to the trails and canyons of the lush Sonoran desert. After a sunset hike to precolumbian petroglyphs, civilization awaits...

Montréal has been described as the cultural capital of Canada, and while Toronto may disagree, a strong argument can be made on behalf of Québec’s largest city. Its mix of anglophone and francophone cultures—as well as the influence of First Nations and other communities—makes its unique, and fascinating. From landmarks that date from the days of New France to the city’s contemporary art scene, here’s a guide to some of Montréal’s highlights.

You’ll go for the fresh fish--namely salmon, black cod, and halibut. But you’ll want to stay forever thanks to the increasingly-excellent restaurant scene. Yes, Alaska is finally on the map when it comes to destination dining. Enjoy one of the state’s top dining spots right outside Denali National Park, stellar wine lists all around Anchorage, and plenty of smoked salmon all down the Kenai Peninsula. Pro tip: Head to the top floor of the Captain Cook Hotel on clear nights for apps and cocktails and a view of Cook Inlet that you’ll never forget.

Many rivers to cross, and beaches to check out, and swimming holes to test: Jamaica offers visitors a busy schedule of taking it easy. When the most difficult hike on your itinerary ends at a rain forest waterfall, you know you’ve come to the right island.

An overnight stay at Tonquin Valley Adventures’ lodge is perhaps the best way to experience the wilderness of the Canadian Rockies. (It’s a well-earned one, too: The lodge lies almost 20 kilometers, or about 12 miles, from the nearest road!) To get there, hike the Tonquin Valley backcountry from Edith Cavell Road to the path alongside Astoria River before reaching the Ramparts Mountains. The setting is surreal, as the lodge has a series of cabins with unforgettable views. A short walk leads guests to the edge of Amethyst Lake, where canoes, kayaks, and rowboats await to take you on your next adventure.

Originally opened in 2006 by chef David Husereau, known for his appearance on Chopped Canada, Evil Dave’s Grill may have since changed ownership, but the menu remains prime-time ready. Try the Cowboy Sushi, the Luscious Lollipop Shrimp, or the Malevolent Meatloaf (best name ever), which is made with 100 percent lean ground bison and wild-boar bacon. Dinner dishes range in price from $23 to $40, and they offer more quality and creativity than most other comparably priced restaurants in town. Pair your meal with a cocktail from the elixirs menu—popular ones include the Karma Police, made from Malibu Mango rum, Hpnotiq liqueur, a mandarin wedge, and ginger ale.

Hit the trails at the Cave Creek hiking area, about 30 miles north of town in the Tonto National Forest, to see the rare crested saguaro cactus in its fantastic fan shapes. Trail number 4 meanders alongside Cave Creek for most of the 10-mile trek, providing many opportunities to dip your toes. The trailhead is located off Forest Road 24, (480) 595-3300. This appeared in the January/February 2013 issue. Illustration by Michael Hoeweler.

Named after the great author from Hannibal, Missouri, Mark Twain National Forest sprawls for more than 1.5 million acres in the Ozark Highlands. The only national forest in Missouri, it’s a treasure trove of outdoor adventure, with 750 miles of trails for hiking, mountain biking, and horseback riding; 350 miles of perennial streams for canoeing, kayaking, and floating; several caves for exploring; and more than 35 campgrounds and picnic areas for relaxing in between activities. The Eleven Point National Scenic River is a particularly lovely area of the park, snaking through the Ozark hills along an underdeveloped, ruggedly beautiful shoreline.