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Elevate the normally mundane experience of shopping for medicine-cabinet basics like soap and toothpaste with a visit to one of the oldest pharmacies in the world. In this 13th-century chapel with early Renaissance frescoes, Gothic carved wooden cabinets, and crystal chandeliers, most items are still crafted according to formulas originally created by Dominican monks. A small museum displays equipment once used to make Santa Maria Novella products, as well as a collection of beautifully painted ceramic jars that held the herbs and powders. Linger a little longer in this fragrant world by ordering a pot of herbal tea or a small glass of one of the historic liqueurs in the tearoom.

Nothing is a more powerful symbol of the City of Light than the Eiffel Tower. Designed by Gustave Eiffel for the 1889 Paris Exposition, it’s one of the world’s most-visited monuments, with nearly 7 million people ascending the 1,062-foot wrought-iron structure each year. Glass elevators spirit you to the top—hardy souls can take the stairs part of way—where in addition to unparalleled panoramic views of Paris, you can toast your arrival with a glass of bubbly at the Champagne bar. Evenings there’s a grand light show: every hour on the hour, the tower sparkles for five minutes with 20,000 bulbs.

There’s only one way to make this journey--by narrow gauge railroad, pulled by a vintage steam locomotive. This is a truly iconic experience in the southwest of the state, and one of the ways to feel the full grandeur of the San Juan Mountains. You board the train in the morning at the depot in Durango, just as passengers have been doing since 1882! The trip takes about 3.5 hours and you can either ride the same train back, or opt for the one-hour bus ride down Highway 550. There are a number of cars and classes to choose from, from standard coach to the Knight Sky, an all-glass carriage in First Class that allows views up the stunning canyons (and not just their passing walls). Tickets start at $85.

This former royal palace is one of the largest museums in the world, and its art collection is considered one of the most comprehensive. It contains around 400,000 works, although—mercifully, perhaps—not all are on display at any one time. There are some pieces that never get taken off the walls. The Mona Lisa and her smile attract millions of visitors each year. Other must-see masterpieces include the sculptures Winged Victory of Samothrace and Michelangelo’s Rebellious Slave, and the Eugène Delacroix painting The Death of Sardanapalus. There’s no real trick to avoiding crowds at the always-packed museum. The best you can do is try to go in the off-season, early or late in the day, and on a weekday. Your chances of being alone with the Mona Lisa will still be slim to none, but you might be able to actually see that enigmatic smile behind the Plexiglas.

While not as large as other ancient Mayan cities in the region, Tulum draws in visitors for its stunning setting of centuries-old temples perched on a cliff by the Caribbean Sea. You’ll pass a large market with souvenirs, a casual Mexican restaurant, and even a Starbucks before reaching the entrance, where a train can take you to the site if you’re not up for the 10-minute walk. It’s advisable to hire a guide to fully understand each structure’s significance and the history behind the ruins; informative signage is all but nonexistent. Don’t forget to bring your swimsuit, as the site encompasses a white-sand beach with soothing waves and beautiful rock formations that’s reached by a long wooden staircase.

The stunning landscape of Salineras de Maras features salt pans that are still used exactly as they were at the time of the Incas. As you make your way through the region, you’ll see people doing the backbreaking work of harvesting salt on small family plots. The reward? The salt gathered here is some of the best in the world. Water, naturally salt-infused, flows down from the mountains and settles in the pans. As the water evaporates, salt remains, to be extracted with simple tools. Stop at a store or one of the many small-scale vendors selling the “fruit” of this labor in its pure form or mixed with herbs for use in cooking, bathing, or chocolate bars.

Mazatlán is going through a renaissance. “The Pearl of the Pacific” saw its original heyday along with Acapulco during the glamorous 50s and 60s, when Hollywood stars mixed with Mexico’s elite for sun and fun and cocktails. By the 90s, however, Mazatlán was worn around the edges and run down, a forgotten tourist relic while the Caribbean coast’s Cancún rose to world fame. Well, Mazatlán is back, baby-- back to its former glory and more. If your hotel is in the touristy souvenir-filled “Zona Dorada” (Golden Zone), be sure to spend your days in the Pueblo Viejo (Old Town) and its charming, fully renovated historic center steps away from the beach. The cultural scene here is vibrant--live theater and dance performances, tasty eateries, unique boutiques, and several interesting museums. Of course, getting out in the sea and sun will also be a priority. Surfing, sportfishing and horseback riding are all popular here, but the real don’t-miss activity is a whale or dolphin-watching expedition. Onca Explorations (www.oncaexplorations.com) offers popular daily ecotours to observe marine mammals. At the end of the day, a drink at a beachside bar is in order. As you people watch and enjoy the dramatic Pacific sunset, you can ponder whether you’re in the mood for watching a concert at the Teatro Angela Peralta or dancing the night away at one of Mazatlán’s many Zona Dorada nightclubs.

Before there were art galleries in Santa Fe, there was La Posada. Built as a private home in the 1880s by wealthy local merchant Abraham Staab for his beloved wife, Julia, the elegant pueblo-meets-Spanish-style complex expanded in the 1930s, when new owners added adobe casitas to the six acres of lush, high-desert gardens—and then invited artists such as Georgia O’Keeffe and Will Shuster to stay and work. When La Posada became a hotel shortly thereafter, the walls were already lined with works by the many artists who continued to pass through. Even now, the lively lounge—a see-and-be-seen spot for artists of all kinds—and the high-ceilinged rooms—with their kiva fireplaces and traditional viga ceilings—are adorned with works by some of the foremost contemporary American artists. All works are available to buy, too, for guests who want to take home a piece of their trip. Or, you can make like most guests, and just keep returning to this refined retreat that has offered respite from the world for more than a century.

Visitors to Santa Fe come in search of art and culture, and it’s hard to trump the cultural experience at the Hotel Santa Fe, the Hacienda and Spa. In addition to being a high-end hotel in the hip, recently revitalized Railyard District, this pueblo-style compound is the first of its kind, the only luxury stay to be owned and run primarily by a local Native American tribe—the Picaris Pueblo.

No top-tier amenity has been left out—the spa is one of the best in town, the restaurant and lounge is one of Santa Fe’s most acclaimed, the gym offers yoga classes, there’s a free shuttle into town—and the guest experience is unlike that anywhere else, thanks to the extensive private Native American art collection that adorns the walls, the handmade local furniture that fills the rooms, and the responsible presence of traditional Native American culture throughout.

The hotel’s gift shop is Santa Fe’s only tribally owned store, selling traditional local handicrafts and art, and events are held throughout the year for guests to learn about Picaris Pueblo culture. And, as if this all weren’t impressive enough, the hotel has a rigorous environmental policy, and its rooms are completely powered by solar energy.

As Santa Fe’s only Native American-owned hotel, the Hacienda & Spa draws on a range of modalities from Swedish, sports, cranial-sacral, and energy work, and it hosts a menu of treatments aptly titled “This Wind and Mountain” and the “Land of Enchantment.” Outside, find three acres of Native American sculptures and gardens to relax in after your day of rest.

Fushimi Inari Taisha on Inariyama mountain is dedicated to the Shinto gods of rice and sake, but Inari is also the god of merchants and that brings a lot of businesspeople to worship here. Everyone else stops by to see the thousands of vermilion torii, or gates (each of which is funded by a Japanese company). They lead to the main shrine, which was built in 1499. Walking underneath the gates is like passing through a fiery tangerine tunnel, and visitors leave behind tiny torii replicas as part of their prayer.

Explore West Virginia’s rugged highlands with scenic trails, stargazing, and time in the creative hubs of Davis and Thomas.

Explore Arizona’s vineyards and desert spas, and a historic dude ranch near Tucson with this eight-day travel itinerary.

Carve through the snow, then unwind at Park City’s best après ski bars and lounges.

Crowds may swarm upon it daily from sunrise onwards, but exposure hasn’t dulled the impact of the largest religious monument in the world. Commissioned by King Suryavarman II in the 12th century as the centerpiece of the mighty Khmer empire, the structure is inspired by Hindu sacred design and is estimated to have taken around 30 years to build. The biggest surprise upon visiting might be learning that the vast complex of spires, moats, frescoes, cloisters, and balustrades was constructed in such speedy fashion. You won’t be alone while witnessing it, but sunrise over the iconic temple remains one of the essential experiences in Southeast Asia. A return in the afternoon when the camera-toting hordes have dispersed is also advisable.

From beginner-friendly climbing and zip lines to epic white-water rafting and a guided Bridge Walk, this national park in West Virginia has it all.