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An active parish of the Roman Catholic Diocese of San Diego, Mission Basilica San Diego de Alcalá remains a tranquil place of worship and reflection. Regardless of your religious beliefs, the first of California’s 21 missions is well worth a visit for its extensive history. It was originally constructed in Presidio Park in 1769 but moved inland to its current site just five years later. Records show that it was the first place in California to cultivate olives; tree cuttings from this mission would later be used to found olive groves at other missions around the state. It’s also home to the grave of Father Luis Jayme, the state’s first Catholic martyr; he was killed when American Indians stormed the mission in 1775 and is now buried next to the altar. Destroyed many times over, the mission was most recently rebuilt in the 1930s, but looks as it would have in the early 1800s.

Starting in 2014, this collection of historic buildings was reinvented as a gastronomic hub—helping to revitalize the city’s downtown in the process. An early 20th-century citrus packing warehouse became the Anaheim Packing House, a virtual United Nations of food: Walking through the 42,000-square-foot hall, you’ll find citrusy ceviche at Urbana, fried chicken sandwiches at Sweetbird, garden-fresh hot pot at Rolling Boil, organic curry at ADYA, and matcha shaved snow at I Am. Craft beer—quickly becoming a signature of Southern California—is in no short supply, thanks to bars like Anaheim Brewery, housed inside a 1925 mission revival building. A circa 1917 marmalade factory became the MAKE Building, where you can linger over a flight of California reds at Pali Wine Co. or a plate of pulled pork at Jav’s Barbecue. The compact district is distinctly Californian, from the succulents and air plants inside to the palm trees and olive groves of Farmers Park outside—a grassy knoll where, at any given time, you might happen upon a free yoga class, a gardening demo, or a live acoustic band playing under the sun.

California’s original Holiday Inn has come a long way. After several iterations—former owners include singer Gene Autry and producer Merv Griffin—the property reopened as Parker Palm Springs in 2004. The hotel underwent a major refresh in 2017, with designer Jonathan Adler combining an electric color palette with irreverent, stylish details like an antique DRUGS pharmacy sign and a full wall of macramé owls. Couples love the rooms featuring private outdoor patios and hammocks that hang above their own sandpits. The 12 stand-alone villas work best for families. But the many shared spaces are what make this a Palm Springs playground for all ages: Wandering around the 13-acre grounds, you’ll encounter a life-sized chess set, a labyrinth of bougainvillea-lined garden paths, three pools (one is adults only), and hanging rattan chairs aplenty. The food ranges from breakfast all day at the upscale diner Norma’s to escargot and steak au poivre at the hushed French restaurant Mister Parker’s. Escape the activity on the ground at the Palm Springs Yacht Club spa, where every treatment is customized and you can easily spend an entire day.

Walk, cycle or people-watch along the shores of Elliott Bay, a downtown stretch known for its circusy flair and spectacular vistas. You can ride the Great Wheel or visit the beloved Seattle Aquarium, home to wolf eels, sea otters, and the world’s largest octopuses. Refuel with chowder from local favorite Ivar’s Acres of Clams, then hit the market’s 200 owner-operated shops, ranging from a radical book collection to the Northwest’s oldest magic store. Just don’t turn your back on the famous salmon-slinging fishmongers: They’ve been known to wallop selfie-photographers with a plastic decoy for yucks!

Pairings are everything at Ram’s Gate, one of the first wineries on the drive to wine country from San Francisco. First is the combination of sights: the wonders of architect Howard Backen’s open-concept tasting room in a refurbished barn and the panoramic vistas of Carneros and San Pablo Bay. Next is the marriage of wine and food—winemaker Jeff Gaffner’s single-vineyard designate chardonnays and pinot noirs matched perfectly with seasonal small bites from executive chef Taylr Benham Cuneo. The most popular tasting is called “Palate Play,” which marries five wines with five dishes from the kitchen. For a truly unparalleled afternoon, book the three-hour Vineyard Table experience, an immersion for four to 10 people that includes a glass of bubbly, a guided tour of the winery and on-site gardens, and a custom-designed meal with wine pairings served at a table in the vineyard. There are other, less involved ways to experience Ram’s Gate: seated wine tastings, stand-alone site tours, and picnics down by the pond. Whatever your fancy, just be sure to make a reservation before you go.

Since 1983, food lovers in the know have headed to Santa Barbara’s renowned Paradise Café. Housed in an early 20th-century brick and stucco building with a relaxed atmosphere, the café’s oak wood grill is fueled by Santa Maria live oak—also known as California live oak—a wood that’s essential for the area’s regional style of barbecue. The flavors brought out by the oak in steaks, pork chops, roast chicken, shrimp and sausage, ahi tuna, rainbow trout, and salmon keep added seasonings to a minimum, so fresh ingredients remain the focus of the menu. The crowd favorite, the half-pound signature Paradise Burger, is grilled over oak, topped with Tillamook cheddar cheese, and placed on an onion roll—and best enjoyed with a glass of Paradise syrah, sourced from local vineyards. If you sit on the patio, give the historic mural more than a glance. It features Leo Carrillo, an old-Hollywood actor best known for his role as Pancho in the television series The Cisco Kid; he is locally beloved for his involvement in preserving and conserving California open spaces.

You will likely see Bronzino’s famous portrait of Eleonora (or Eleanor) de Toledo, in the Uffizi, during your visit to Florence. The Spanish noblewoman who became the duchess of Florence in 1539 when she married Cosimo I de’ Medici was unusual for her time, playing an active role in politics and as a patron of the arts. Her patronage extended to garden design, in its infancy (at least in Europe) in the 16th century. Eleonora commissioned the Boboli Gardens behind the Pitti Palace as a green escape from the city; they continue to provide a retreat for travelers today.

Among the earliest examples of the formal compositions that would dominate garden design through the 20th century, the grounds are dotted with classical statues and fountains while straight axes run up and down the hillside with an apparent disregard for topography. A moment in design history can be experienced first hand here. There’s a feeling that the man who planned the gardens (Niccolò Tribolo) conceived a formal plan and then simply laid it atop the site. Principles of garden design were later to shape city planning. The allées of the Boboli Gardens were early models for grand boulevards leading the eye to distant monuments. One of the pleasures of gardens, however, is that you don’t need to know their histories to enjoy the flowers in bloom or the sounds of birdsong and splashing fountains.

Aspen is a playground for the active traveler. No matter how many times I visit, I always set aside time to bike to Maroon Bells. Rent a bike from the Hub, a cycling store in town, and be sure to bring a water bottle and even some snacks for energy. The 11-mile ride from downtown will have your quads (and lungs) burning as you slowly make your way uphill. The steady climb makes about a 1,630-foot elevation gain. The views at the top are worth your efforts. The Maroon Bells and Maroon Lake are one of the most photographed areas in North America. On a sunny day the lake takes on magical turquoise and green hues. Relief comes on the ride back to town, which is all an easy coast downhill. Couch potatoes can opt to take a bus to the top.

If, like most visitors, you head for Tucson between Thanksgiving and Easter, you’re probably seeking sun and warmth while the rest of the country deals with the winter blahs. And you’ll most likely find what you’re looking for. There’s a reason why golfers, cyclists, hikers, and runners flock to southern Arizona this time of year. But, once or twice a decade, the lush Sonoran desert might get a snowfall—it never lasts for long, but every saguaro, ocotillo, cholla, and prickly pear cactus will be edged in ephemeral white. As soon as the sun comes up over the mountains, you’ll start hearing the drip drip drip of the inevitable melting...And by the next day you’re likely to be wearing shorts again. Saguaro National Park, which flanks both the western and eastern edges of Arizona’s second-largest city, is the ideal place to go for a hike in the rare desert snow. The Eastern (Rincon Mountain) division of the park has a hilly eight-mile one-way loop road with access to numerous trails. Drive slowly and yield to the runners and senior-citizen-cyclists-in-spandex with thighs of steel. Get out and up into the saguaro-studded hills before the unlikely landscape disappears...Keep your eyes open for bobcats, mule deer, and the pig-like javelina. (You’re less likely to encounter a rattlesnake in the winter months, but this is still desert wilderness.) And if there’s no snow, you might be treated to spring wildflowers. Don’t forget your sunscreen...

There’s a reason this is one of the most iconic spots along the Grand Canyon. Located on the Havasupai Indian Reservation and hidden deep within a 20-mile round-trip hike, Havasu Falls’ sparkling turquoise waters are a popular destination for seasoned hikers who come for the amazing views, rock climbing, and swimming. The hike to the falls and back is best enjoyed with a preplanned route and plenty of stops for rest, food, and water. Because tribe members of the Havasupai, which means “people of the blue-green waters,” maintain the trails and work to keep their land as unspoiled and pristine as possible, reservations for campsites are limited and day hikes and drones are not allowed.

One of the best views of Florence can be savored from the Piazzale Michelangelo, a short walk across the Arno River from downtown Florence. For a fun afternoon head to the square and enjoy an enchanting panorama of the city, followed by a relaxing alfresco lunch at one of the nearby restaurants. The Piazzale Michelangelo is also worth a visit at night to get a very different glimpse of Florence. The lights of the Duomo and the buildings surrounding it make for a magical nighttime scene.

In 1989, Chilean winemakers Augustin and Valeria Huneeus happened upon a 280-acre parcel of land in the heart of Rutherford that had never been planted with vines. The couple jumped and bought it. The result is Quintessa, one of the most spectacular estates in the Napa Valley. Today there are three different ways to experience Quintessa—all visits are privately hosted and tailored specifically for each guest. The Estate Tasting includes a walk to a scenic viewpoint, followed by a seated sampling session in the main winery building. The “Quintessential Quintessa” includes a scenic drive to a private tasting pavilion atop Dragon’s Hill, which offers unrivaled vistas of the entire valley and revolves around narratives about the property, the terroir, and how winemaker Rebekah Wineburg plies her craft. Finally, the third—and most exclusive—option, dubbed the “Collectors Experience,” offers at least three wines from the Huneeus family cellar, poured alongside the most current release. Time the visit right and Augustin Huneeus himself might come out in his signature cowboy hat to say hello and regale your group with stories of his life in South America before he emigrated to the United States.

Spread across 220 acres of coastal valley, the Ojai Valley Inn opened in 1923, originally commissioned by an early 20th-century glass tycoon. With white stucco and terra-cotta buildings, the mission-style retreat looks like a dreamy California village wedged between the Pacific Ocean and the Topatopa Mountains. Luxurious spa penthouses are ultra-private, and their location in the Spa Ojai building gives guests an easy route to their warm Himalayan salt stone massage or sound energy therapy treatment. The Hacienda Penthouse, atop a hillside villa, brings an air of Morocco to the California landscape. Wallace Neff Historic Rooms, built in the early days of the property, offer the relaxed glamour of that era. Days can be as peaceful or as action-packed as you like and may include golfing at the Ojai Country Club, blending essential oils in the on-site apothecary, lounging next to one of the property’s several pools, hiking, horseback riding, or indulging in retail therapy at two on-site boutiques. Olivella serves traditional and modern interpretations of Italian cuisine, while The Oak’s dishes highlight the resort’s herb garden. Pro tip: Order the signature lavender lemonade.

Throughout his life, African-American artist Noah Purifoy reimagined junk as art, using found materials to create sculptures inspired by Southern California’s culture and landscape. Some of his best-known pieces were made out of charred debris from the 1965 Watts riot, and he worked tirelessly to bring art programs into the local community and prison system. Then in the late 1980s, Purifoy moved to the desert, where he spent the last 15 years of his life creating his original and distinctive magnum opus: a series of large-scale sculptures sprawled across 10 acres of sandy red earth in the Mojave. The space redefines the notion of a museum, with an atmosphere that’s both meditative and reminiscent of Mad Max. While the found items are evident upon close inspection, the impact of the pieces themselves—with such titles as “The White House,” “Band Wagon,” and “Ode to Frank Gehry”—is deeply moving. The museum is open all day and free (though donations are encouraged), but you can also schedule a one-hour group tour or a private tour with a docent. Pro tips: Visit as early as possible or at sundown to avoid the scorching heat and experience the place at its most picturesque. Bring water and watch out for snakes.

The second location of the Sydell Group’s New York flagship, NoMad Los Angeles embraces its past as the Bank of Italy—imposing columns and all. In the lobby of the landmarked building, much of the original Neoclassical style, such as the Doric columns, coffered ceiling, and marble floors, was preserved, complemented by the addition of floral textiles in rich jewel tones. Even the original vault, which once housed 12,000 safety deposit boxes, and its 50-ton door were kept intact. The color palette across the 241 lavish rooms draws from the exquisitely maintained gold-and-blue Italianate lobby ceiling, with custom furniture, original artwork from design studio be-poles, and freestanding bathtubs in most rooms adding to the luxurious feel. Details like nightly turndown service, marble bathrooms, and custom linens by Bellino mean a five-star stay is all but guaranteed.