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Run by well-known chef Jeff Balfour, Southerleigh brings cross-cultural cuisine to the bustling Pearl Brewery complex. Here, the seasonal menu ranges from crispy fried half-chicken with coffee-crusted bacon and thyme red-eye gravy to Gulf red snapper with charred tomato sauce piquant and pickled fennel salad. Housed in a historic building that was once Pearl’s Brewhouse, Southerleigh also references its past with an on-site brewery and nearly two dozen beers on tap.

Founded in 2002, Big Lou’s is famous for its enormous pizzas. Ringing in at 42 inches, the pies have been featured everywhere from the Food Network to the Travel Channel’s Man vs. Food. Cover yours in classic toppings, or order specialty versions such as the white, the veggie, or barbecue, which comes slathered in two types of cheese and barbecue sauce. In case you’re not a pizza person, the menu also features wings, salads, sandwiches, calzones, and pasta.

The name says it all: To dine at Bliss is pure euphoria. In an intimate space with just 52 seats, this Southtown restaurant offers a dining experience you won’t soon forget. Mixing hearty classics with Southwest-inspired cuisine, the menu ranges from braised beef short ribs with buttery mashed potatoes to vegetarian enchiladas stuffed with roasted butternut squash, cremini mushrooms, zucchini, bell peppers, eggplant, and cheese. Appetizers are equally enticing, especially the Japanese hamachi sashimi tostadas and the oyster sliders, served with candied bacon on buttermilk chive biscuits.

This travel-inspired eatery got so popular that it moved to a larger space on University Avenue in August 2017. Once in the new location, executive pastry chef Kristianna Zabala was able to expand her menu (which changes daily) to include breakfast sandwiches and Montreal-style bagels alongside her usual blood-orange-Creamsicle and blueberry-lavender doughnuts. Available in a range of creative flavors, Zabala’s signature creations feature organic eggs and fresh ingredients from local farmers. Don’t leave without trying the classic ube-taro-coconut variety or the white-chocolate-mint-glazed doughnut with a passion-fruit-jalapeño drizzle, if they are available.

Walk the long shop-lined Via Capodimonte (or, if you are feeling particularly industrious, climb the 921 Phoenician Steps to the very top) to reach the former home of the Swedish physician and author Axel Munthe. This 20th-century mansion, now a museum with magnificent gardens, sits almost 1000 feet above the sea and offers unbelievable views over Capri and toward Naples and Mount Vesuvius. During your visit, follow tradition and make a wish with your left hand touching the ancient Egyptian sphinx statue. There is a café at the top of the gardens and occasional live music on summer evenings.

Deli Board, a small SoMa joint, is nirvana for sandwich lovers, with offerings made from the best ingredients found this side of Cleveland, which is where owner Adam Mesnick grew up. Design your own creation from a selection of bread, meats, and extras (pickles and cherry peppers are a must), or order one of his predesigned, prenamed beasts, which are piled-high combinations of meat, veg, sauce, and extras. Zeke is a Californian’s favorite, with turkey, avocado, bacon, cream cheese, pickled onion, sprouts, and mayonnaise on a French roll, while the Leroy Brown satisfies carnivorous cravings with Romanian pastrami, turkey, kosher salami, American cheese, Muenster cheese, pepperoncini, pickles, and homemade sauce. Check the website for daily specials, or just drop in to stock your picnic basket.

Della’s, the breakfast-and-lunch-only restaurant at the Delano Las Vegas, prides itself on sourcing ingredients from local farmers and growers—yes, they really exist in the middle of the Nevada desert. The menu has options that can satisfy diners with all sorts of dietary restrictions: vegan, gluten-free, vegetarian, and more. For breakfast, you can taste the difference that comes with farm-fresh produce, especially in the egg dishes. At lunchtime, the off-menu ramen bowl features a savory mushroom broth with a pork shank, house-fermented cabbage, and a slow-poached egg. Della’s is also one of the only places on the Strip where you can get cold-pressed juice made to order. The overarching commitment to sustainability extends beyond the menu: Glasses here are created from recycled liquor bottles from Vegas clubs.

Located on the second floor of the Fretheim Hotel, Arven has grand views of the mountains and the fjord. The emphasis here is on quality meat and produce sourced from nearby farms. In addition to the à la carte menu, there’s also a buffet that serves an assortment of salads, meat and fish. Expect dishes such as roasted veal served with cabbage, roast parsnip and beer sauce and rhubarb soup with sour cream sorbet.

It took 424 years to build this Gothic showpiece, but considering the hundreds of sculptures jutting out from the facade, the timing is almost understandable. At 466 feet tall, the Strasbourg Cathedral was, from its completion in 1439 until the mid-19th century, the highest Christian structure in the world. Today, it’s fallen to sixth place, but its frontispiece is still considered one of the greatest medieval picture books of all time. Inside, a gander at the 12th- to 14th-century stained glass and organ (with parts dating back to 1385) is optional, but climbing the spire’s 322 steps to enjoy panoramic views over the city as far as Vosges and the Black Forest is pretty much obligatory. Make sure your visit coincides with the 12:30 p.m. hour, when the cathedral’s astronomical clock comes alive with apostles parading before Christ.

First opened in 2004 in a former office building in the Central Business District, the Loews New Orleans Hotel completed a $4 million renovation in November 2014. The new look is modern, but with a nod to the Big Easy: rooms and suites (which, by the way, are among the most spacious in town) are done up in soothing blues and grays, and feature local photography on the walls, and the carpets have a wrought-iron fence motif. Large picture windows afford vistas of the city or the Mississippi River.

Run by the legendary Brennan family and named after the vivacious Adelaide Brennan, the hotel restaurant also got a makeover—think canary-yellow seats, teal tufted banquettes, and Andy Warhol–esque pop art of its namesake.

Opened in April 2015, this is one of the newest additions to New Orleans’ hotel scene. It’s also one of the most unique. Set in an 1854 warehouse near the Port of New Orleans, the property pays homage to its past as well as to its Arts District location. The look is contemporary industrial, with plenty of original architectural details (hardwood floors, exposed piping and brick, wall-to-wall windows) paired with Tivoli radios, flat-screen TVs, free Wi-Fi, and other modern conveniences. The hotel lobby is part art gallery, with a rotating collection curated by the New Orleans Center of Creative Arts, part commissary, with locally crafted products displayed in chandlery cases, and part coffee shop, with pastries from the neighboring restaurant—which is one of the hottest openings this year.

Compere Lapin (French for “brother rabbit” and also a fictional character in Caribbean and Creole folk tales) serves food that draws on chef Nina Compton’s island roots, classic French training, and traditional Creole fare. The result is wonderfully colorful dishes like conch croquettes with pickled pineapple tartare sauce, roasted jerk corn with aioli and lime, and curried goat with plantain gnocchi and cashews.

First opened in 1893 as Grunewald Hotel, this historic building stretches an entire city block and has a storied past that’s equally expansive. The Roosevelt has played host to presidents and senators, duchesses and dignitaries, actors and actresses. Huey Long kept a suite here in the 1930s and could often be found propped up at the Sazerac Bar (where his go-to cocktail was the Ramos Gin Fizz). Entertainers from Ella Fitzgerald and Frank Sinatra to Tina Turner and Ray Charles have performed in the Blue Room.

A $145 million rehab, completed in 2009, restored the hotel to its former glory. Now part of the Waldorf Astoria Collection, the property combines the grandeur of yesteryear with all the trappings of a modern luxury hotel—including a lavish Waldorf Astoria Spa and a hip Italian eatery.

If there were ever a hotel with history, it’s the Singular Patagonia. Opened as a hotel in November 2011, the original building once served as a post-Victorian cold-storage factory built by the British in 1915 for the purpose of processing sheep’s wool and meat to be shipped back to England. Overlooking the waters of Last Hope Sound, the long, red-brick building is located just outside the town of Puerto Natales. After operating for almost 70 years as a factory, it was declared a national historic landmark before being transformed into a luxury hotel.

History is by no means forgotten. The hallways are still stocked with brightly colored machinery—from steam condensers to boilers and forges—all stamped with the name of the British city in which they were built: Derby, Birmingham, London, or Glasgow. Designed by Chilean interior designer Enrique Concha and local architect Pedro Kovacic, the 57 bedrooms stretch along a new wing that was added to the original buildings, and these rooms are furnished with Victorian-inspired furniture.

To many gastronomes, the subtle flavors and spicing of Khmer cuisine makes it one of Southeast Asia’s great food secrets. That’s certainly the view of French chef Joannes Riviera, who has taken inspiration from Cambodia’s unsung culinary traditions to create one of the region’s biggest restaurant success stories. Cuisine Wat Damnak has received numerous accolades since opening for business in 2011. Using only the freshest local produce (think juicy tropical fruit, bamboo shoots, and fish from nearby Tonle Sap), Riviera devises regularly changing tasting menus that burst with creativity. Recent hits include a fish sour soup with green banana and rice paddy herb, and a duck confit curry with fresh rice noodles. Dinner is a steal at just $27 for five courses or $31 for six.

The fragrant, pleasingly cluttered Central Grocery is a holdover from an era when Italian-run groceries occupied storefronts throughout the city. This timeworn shop across from the French Market still boasts an old-world charm, filled with tall shelves crowded with imported goods and various whatnots, mostly Italian. But that’s not why you’ll see lines out the doors. The crowds are clamoring for muffulettas, classic New Orleans sandwiches that originated here about a century ago. (Slogan: “Imitated by many, but never duplicated.”) A muffuletta comes on a type of round, flattish loaf (not unlike a focaccia) that originated in Sicily. The details may vary, but it typically includes cured meats (capicola, salami) and cheese (provolone). What distinguishes it from a hubcap-shaped hoagie is the topping—a tangy marinated-olive salad. Know this: You don’t need to order a whole one; a quarter-sandwich is still plenty filling for one person.