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Overlooking a postcard-perfect Venetian street (a former canal, now paved over) in the artistic Dorsoduro district, this 500-year-old merchant’s townhouse has been revamped as the boutique hotel Ca’Pisani. Behind the traditional exterior lies a modern den with clean lines and sharp, geometric forms that’s enhanced by original work from one of Italy’s most notable Futurist artists, Fortunato Depero. Architects Roberto Luigi Canovaro and Pierluigi Pescolderung balanced original design elements—exposed beam ceilings, brickwork—with 1930s touches, including one-of-a-kind inlay door designs and custom masonry and marble work.

Gaze out at the city’s rooftops from the hotel’s roof terrace, or mingle with locals over wine or an espresso at the street-level café. With the Peggy Guggenheim collection and the Gallerie dell’Accademia gallery just a stroll away, you’ll be able to journey from 16^th-century Venice to the 20^th century all in a few famous paintings.

An understated, private landing stage for gondolas and water taxis on a side canal of the lagoon marks the entrance to the lovely Baglioni Hotel Luna in San Marco. Steeped in history, the palazzo, with lagoon-facing windows and charming Juliet balconettes, dates to the 12^th century and is said to have given refuge to the Crusade-era Knights Templar. Interiors are more in keeping with noble 18^th-century fashions. There’s a sleek marble lobby, sparkling crystal chandeliers, antique furnishings, and a healthy showing of brocade fabrics. The standout room is the pristinely preserved Salone Marco Polo, filled with18^th-century frescoes painted by pupils of influential Venetian painter and printmaker Giambattista Tiepolo.

Conveniently located just steps from bustling and culture-packed St. Mark’s Square, this hotel, with its award-winning restaurant, relaxed lounge, and rooms full of delightful period details, makes for an elegant home base in Venice.

Opened by Carlo Ritz in 1894, the St. Regis belongs to a particular category of five-star hotels in Rome in which Old World glamour is alive and well. While the current trend in town is toward boutique hotels and converted townhouses, the St. Regis is palatial and uncompromisingly opulent. In the century (plus) since opening its doors on the crest of the Quirinal hill, the hotel has remained a beacon of luxury, and indeed many of the hotels on the nearby Via Veneto, Rome’s luxury hotel row, take their cues from this long-established pioneer.

The entrance through the marble portico just off Piazza della Repubblica leads directly into a grand salon furnished with overstuffed chairs, chandeliers, and antiques. The grandeur continues in the rooms, where classic style and sophistication reign. Owing to its elite clientele, the hotel’s 23 suites come with 24-hour butler service, while the aficionado program is designed to provide exclusive access to sites and special experiences including road trips designed by the Ferrari racing team or helicopter rides to wine estates.

This family-run hotel, originally opened in 1886, is steeped in history from its classic furnishings to its esteemed guests. Literary legends William Faulkner and Ernest Hemingway have stayed here; Tennessee Williams wrote about the hotel in his play The Rose Tattoo, and Truman Capote was known to prop up the Carousel Bar & Lounge on many a night. The merry-go-round–like bar (which makes a complete revolution every 15 minutes) is probably the hotel’s most famous feature, and a Vieux Carre cocktail there is de rigueur. Guests will also want to visit on-site restaurant Criollo, which offers an updated take on traditional N’awlins fare.

Gothic and grand, this 18th-century former nobleman’s home stands proudly on the banks of the Grand Canal in the San Marco district. Venetian-born owner and interior designer (among her many talents) Francesca Possati has restored this historic home to its regal glory. She has worked with local artists to breathe new life into original woodwork, ornate trompe l’oeil ceilings, and silk wall hangings, resulting in a once-again polished and posh palazzo. The distinctly Venetian rooms—many with canal views—are styled with rich fabrics, bold wall coverings, and pristine period antiques and illuminated by Murano glass chandeliers. Of course, they’ve been updated with the latest modern perks (like Italian marble and whirlpool tubs in the bathroom).

Stroll the art-filled hallways, splurge for a tasting menu at the elegant restaurant, and watch the gondolas float by from the red-awninged terrace. La dolce vita, indeed.

The D.O.M., which opened in late 2013, is a five-star boutique hotel in the heart of Rome’s historic center. Originally built as a 17^th-century noble palace, the property was subsequently converted into a monastery, then Ministry of Justice offices. Its current design, which blends architectural elements from its previous uses, was entrusted to architect Antonio Girardi, who has seamlessly married Renaissance reverence and modern design.

Thanks to the previous ecclesiastical incarnation, rooms are intimate and many have low ceilings. Dark gray and brown hues mingle with velveteen, brick, and wood, creating a cavernous feel in the ground-floor common areas, which contrast with the bright and open rooftop terrace and its views over Rome’s Renaissance quarter and across the river to Trastevere. On the ground floor, a small reception area precedes the hotel bar and restaurant, as well as a small enclosed terrace.

First opened in 2004 in a former office building in the Central Business District, the Loews New Orleans Hotel completed a $4 million renovation in November 2014. The new look is modern, but with a nod to the Big Easy: rooms and suites (which, by the way, are among the most spacious in town) are done up in soothing blues and grays, and feature local photography on the walls, and the carpets have a wrought-iron fence motif. Large picture windows afford vistas of the city or the Mississippi River.

Run by the legendary Brennan family and named after the vivacious Adelaide Brennan, the hotel restaurant also got a makeover—think canary-yellow seats, teal tufted banquettes, and Andy Warhol–esque pop art of its namesake.

Hilton Molino Stucky on Giudecca Island is a zippy five-minute boat ride (free for guests) away from bustling Piazza San Marco, and ideally located for those craving a tad more tranquility without missing out on any of those sweeping Venetian vistas. Once a working flourmill, this brick, industrial-era fortress has been reimagined as a luxury hotel with all of the modern bells and whistles. Take a break from museum hopping with a day spent surveying the city below from the city’s only rooftop pool (followed by quality time spent in the spa). Of course, with several dining options just steps from your room, you could happily spend most of your time right here.

If mixing business with pleasure, this hotel—with Executive Suites, a ballroom for events, several conference rooms, and a business center—makes for a superbly scenic day at the office.

Houston’s first boutique hotel, the Lancaster is also the oldest continually operating hotel in town. Built in 1926 by Sicilian-born Houston investor Michele DeGeorge, it’s now owned by Texas-based hoteliers Matthew Newton, Jay Shinn, and their respective families, all of whom work hard to maintain the hotel’s reputation for personalized service and classic style.

Extensive renovations following Hurricane Harvey brought classic Regency style to the traditionally Italiante property, from clean, elegant lines to a more-open floor plan. The hotel also added a focus on visual arts, bringing in a collection of more than 200 contemporary works by renowned Texas artists to be displayed throughout the public spaces, suites, and 93 guestrooms. Rich in Houston history, the Lancaster was named a Texas historic landmark in 1984 and is now the city’s only member of Historic Hotels of America. Rooms are comfortable and immaculate—albeit cozy quarters. And just as if you were a guest in a friend’s home, there’s complimentary Wi-Fi and a full-service American breakfast buffet with coffee, housemade scones, granola, fruits, farm-to-table eggs, bacon, and sausage. At on-site restaurant Cultivated F+B, guests can also look forward to contemporary American dishes like deviled eggs, braised short rib tacos, and cast iron–seared scallops.

Occupying what were the Maison Blanche department store and the S.H. Kress & Co. five-and-dime, this stately hotel first opened its doors in 2000 after a $250 million overhaul of the then-shuttered Beaux-Arts buildings. After Katrina, the property underwent a second renovation, which included the expansion of its spa (now a sprawling 25,000 square feet) and the addition of a private entrance for Club level guests.

This is a Ritz-Carlton, so you can expect the same (high) level of service and luxury—think ornate furnishings, sumptuous linens, and a $3.5 million art collection—as at other properties within the brand. But the property isn’t just another Ritz. Bellmen wear seersucker, the bistro serves po’ boys, and there’s live jazz in the lounge (which also serves a mean Vesper).

Opened in April 2001, this Central Business District property, a converted dry-goods warehouse, is a departure from the typical New Orleans hotel. Instead of fleur-de-lis wallpaper and Louis XIV chairs, you’ll find Fortuny lamps, Herman Miller desk chairs, and Agape “Spoon” tubs in the palatial bathrooms. The 18 lofts (two are penthouses), with their white walls, concrete floors, and modern furnishings, feel straight out of the pages of Dwell.

The hotel doesn’t have the amenities of a larger hotel; the lobby is meant for checking in, not hanging out, and there’s no restaurant or bar to prop up, but guests have privileges at the sister hotel, International House. And, most significantly, the fact that there are just 18 rooms means that from the minute you check in, the front desk team knows you.

Since its founding in 1893, the Hassler has been a pillar of luxury accommodation in Rome. This five-star hotel is perched theatrically atop Trinità dei Monti, the hill at the apex of the Spanish Steps, providing dazzling vistas over Rome’s rooftop terraces and church domes. More than a century after opening, the hotel remains privately owned. Generations dedicated to carefully cultivating a loyal clientele have made the Hassler the destination of choice for many royal and celebrity visitors to Rome. Accordingly, the staff is well-equipped to fulfill every imaginable whim and desire, regardless of how outlandish.

The formal service and decor hark back to the last days of the Grand Tour when European and American elite converged on Rome for its cultural—and couture—offerings, a tradition that still thrives in places like this. The Hassler oozes Old World charm, and its nearly 100 rooms are clad in marble, embellished with antiques, and accented with gilded furnishings, a reminder of the city’s late 19^th-century splendor. The common areas are similarly lavish and offer palatial settings for meetings, cocktails, and lounging.

Just across the Piazza Trinità dei Monti, the Hassler’s second property, Il Palazzetto, offers accommodations with a lot less gilding but no less class.

The doorway of the Portrait Roma is one of a growing number of blink-and-you-miss-it boutique hotel entrances behind which contemporary luxuries await. Tucked behind an unassuming facade on a side street off the busy Via dei Condotti, the Portrait Roma is part of the Lungarno Collection, a small group of boutique hotels owned by the Ferragamo fashion house. Opened in 2006, the property prides itself on customized service, and each of the rooms comes with a Lifestyle Manager, or 24-hour concierge, who provides personalized holiday management throughout the stay based partly on the guest questionnaire completed before arrival.

All 14 rooms are suites, and each is classically decorated and designed to mirror the prestige of the Ferragamo brand. Rooms are accented with linen, leather, and cashmere, as well as artwork that evokes the beauty and spirit of Ferragamo. Weather permitting, the rooftop terrace hosts food and drink service and offers views of the historic center.

Small and intimate, Hotel Casa Oaxaca feels quintessentially Oaxacan: It’s colonial in style, with whitewashed walls contrasting with vivid pops of carnelian red and fuchsia. It’s surrounded by local vegetation. And it’s filled with Oaxacan handicrafts and art. Common areas invite visitors to settle in and relax, like the on-site library, pool, and terrace with beautifully-made cotton hammocks. The hotel’s seven rooms are arranged around the central patio. Visitors consistently say the service is exceptional, with attention to detail and a “go the extra mile” attitude mentioned frequently as one of the main reasons to return. Another is the hotel’s central location, as it offers an easy walk to many of Oaxaca’s top sights.

Opened in April 2015, this is one of the newest additions to New Orleans’ hotel scene. It’s also one of the most unique. Set in an 1854 warehouse near the Port of New Orleans, the property pays homage to its past as well as to its Arts District location. The look is contemporary industrial, with plenty of original architectural details (hardwood floors, exposed piping and brick, wall-to-wall windows) paired with Tivoli radios, flat-screen TVs, free Wi-Fi, and other modern conveniences. The hotel lobby is part art gallery, with a rotating collection curated by the New Orleans Center of Creative Arts, part commissary, with locally crafted products displayed in chandlery cases, and part coffee shop, with pastries from the neighboring restaurant—which is one of the hottest openings this year.

Compere Lapin (French for “brother rabbit” and also a fictional character in Caribbean and Creole folk tales) serves food that draws on chef Nina Compton’s island roots, classic French training, and traditional Creole fare. The result is wonderfully colorful dishes like conch croquettes with pickled pineapple tartare sauce, roasted jerk corn with aioli and lime, and curried goat with plantain gnocchi and cashews.