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The lifeblood of modern Istanbul is the two-mile-long pedestrian street Istiklal Caddesi (Independence Avenue), running from Taksim Square to the Tünel train station. It’s equal parts touristy and local, commerce and culture, and strolling down the avenue to shop, dine, or just socialize is a favorite pastime of many Istanbullus. (The beloved red-and-white tram is out of service for the foreseeable future while the street gets some much-needed maintenance.) Though many complain about encroaching international chain stores and shopping malls taking the thoroughfare’s distinct character away, there are still plenty of gems if you follow the backstreets and duck into the historic passages. Don’t forget to look up: Many of the art nouveau and Ottoman-era buildings house rooftop cafés and businesses above street level.

Since its founding in 1903, the DMA (as locals call it) has grown to become one of the top 10 largest museums in the country, with a permanent collection of over 24,000 works culled from around the globe and spanning over 5,000 years of history. Works by boldface Western names like Renoir, van Gogh, Warhol, Rothko, O’Keeffe, and Wyeth lead to extensive collections dedicated to art and antiquities from Africa, Asia, and South America; in between, limited-run exhibits might focus on Native American works, Asian textiles, or emerging contemporary artists. In addition to hosting popular events that engage the whole family, the museum is also committed to supporting Texas artists via foundations and special programs, and offers a searchable Texas artists database to help spotlight these native sons and daughters. Dine on casual, gluten-free Mediterranean fare at the plaza-side Socca, or head to the ever-popular DMA Cafe—set in a striking atrium—for globally flavored dishes inspired by works in the permanent collection.

For the time it takes most Angelenos to commute to work, you can be ferried into the alternate reality of Catalina Island, a romantic escape far from the daily traffic jams and urban sprawl. The evergreen-shrubbed hills spotted with an artists palette of summer homes and surrounded by bright hues of blue waters, coves and marinas feels more like the islands off the coast of Spain than the United States. It is rejuvenating to arrive at a place so close to the city yet feel so completely removed.

If these walls could talk they’d recite plans for military campaigns and tales of love, lust and betrayal that make this former residence and imperial seat of the Ottoman Empire so intriguing. Walk the dazzling tile-and-mosaic-lined corridors, see the jewels the sultans wore, the baths where they washed, the rooms where they entertained, the quarters that housed their concubines, and the kitchens that created feasts for 5,000 residents.

Charlie’s is old-school New Orleans writ large. It’s one of a handful of surviving notable neighborhood steak houses (it’s not far from where the original Ruth’s Chris was also once a neighborhood spot), a no-frills joint with faux-wood paneling on the walls and no menus to hand out. The waiters ask you what size you want, and also if you’d like to start with an order of fried onions. (The correct answer is yes.) Pro tip: Kick off your evening an hour earlier and a couple blocks away at Pascal’s Manale with a dozen or two bivalves at the marble oyster bar of a revered Italian-Creole “red gravy” spot.

Housed across a 1940s mansion and modernist tower, Casa Fayette is a stylish boutique lodging inspired by Guadalajara hometown hero Luis Barragán. With the architect in mind, Milanese interiors firm Dimore Studio designed the hotel’s 37 rooms in a Mexican palette of artichoke, salmon, and burgundy, adding a mix of custom and European furnishings by the likes of Pierre Frey and Michael Thonet. Downstairs, public spaces take on a global-chic aesthetic informed by the surrounding Lafayette neighborhood. Graphic cement tiles line the pool and spa area, while a glam brass-and-wood bar complements tropical-palm-patterned seating in the restaurant.

Beachy espadrilles, cloth bags printed with cheeky Italian phrases, and colorful Cruciani bracelets are just some of the fun inventory found in this small, stylish shop. There’s a little bit of everything here: bikinis and summery dresses, art books, and local crafts like an arty ceramic interpretation of il ciucciariello, the little donkey that is the local symbol for good luck. The shop also stocks useful maps of the many paths and beaches along the Amalfi Coast.

Finding good Italian food in Asia can be as daunting as Monty Python’s quest for the Holy Grail, which is which why Latteria Mozzarella Bar is so special. The Duxton Hill restaurant boasts nearly a dozen varieties of mozzarella to try, from burrata with roast pumpkin and truffle to smoked buffalo-milk mozzarella with porcini mushrooms. Fish, meat, and pasta mains round out the offerings; savor the homemade red tagliolini with pork sausage ragù, the gnocchi with porcini and truffle cream, or the slow-roasted lamb shanks with chickpeas and red wine. If you’re lucky, you’ll snag a seat on the gorgeous terrace.

This quirky Pompeian red house in Anacapri, Italy, was built by a Confederate officer who fled the United States after the war. His several archaeological finds from the region and beyond are on display in the house, some built right into the walls. Over the front entrance, embedded in the Byzantine-style mosaic, is a Greek phrase that translates to “hail citizens of the land of leisure.” The house is now a small museum to a collection of early 20th-century oil paintings of Capri and Naples. In a corner room on the top floor, you can see some ancient statues that were fished out the Blue Grotto during two different excavations over the past few decades.

Les Houches bills itself as Chamonix’s go-to resort for families. And nothing encapsulates its relaxed, enjoyable atmosphere more than its outdoor ice rink. Located in the heart of the village, this popular spot not only provides a beautiful backdrop of Mont Blanc (check out the late-afternoon illuminations), it’s also free to use. Once the last shards of crimson glow have left Europe’s famous mountain range, skaters carve along under the stars—as late as 11 p.m. on Wednesdays and Fridays, with music playing throughout. Note: The rink is open from late December through the end of March, and ice-skate rentals cost € ($3.50).

The Galleria Borghese, which is set in the large public Villa Borghese park, was born in the 16th century as the collection of Scipione Borghese, a powerful Cardinal and nephew to Pope Paul V. The Cardinal amassed an enormous number of ancient sculptures, many of which are displayed on the ground floor where several Bernini statues and Caravaggio canvases also appear. The upper story, on the other hand, is home to Renaissance and Baroque paintings. Seek out Titian’s Sacred and Profane Love, Raphael’s Deposition, and Cranach’s Venus and Cupid. Unlike other collections of the era, which were kept in private palaces, the Borghese collection was intended to be open to the public, much like the surrounding grounds known as the Villa Borghese. The family collection is now property of the Italian state. Due to its dimensions and popularity, visits are limited to a fixed number of visitors every two hours and for a maximum of two hours. Be sure to book tickets well in advance and don’t bothering going to the museum without a booking.

At Zupperia, it’s all about the soup—which makes this local favorite the ideal place to duck into after exploring Bergen on an icy cold day. Launched from humble beginnings, Zupperia is now one of Bergen’s most popular eateries, with four locations across the city. For a taste of Norway, go for the creamy fish soup or the reindeer and mushroom version, known as Rudolph Soup. International flavors are just as popular, including the creamy Thai favorite tom ka gai and the Eastern European–inspired goulash. Service is not the speediest, but the budget-friendly prices more than compensate. If you’re hungrier, a full range of main dishes is also available.

Dating back to 803 C.E., the St. Peter Stiftskulinarium is said to be the oldest restaurant in Europe. While there’s a fine contemporary Austrian menu, the history and atmosphere of the various salons and dining rooms are an even bigger draw. The arcaded courtyard in particular is charming and turns into a winter wonderland during the Christmas-market season. The highlight for most travelers will be the Mozart Dinner. Taking place in the stunning ambience of the Baroque Hall, the meal is served with a performance by an ensemble of Mozarteum University Salzburg graduates wearing period costumes—wonderful musicians who also work with renowned orchestras.

Though from Guadalajara (he never let friends forget), Pritzker Prize–winning architect Luis Barragán lived much of his life in Mexico City, where he designed and constructed this, his last residence, completed in 1948. A UNESCO World Heritage site, the home is open to be toured by small groups—by appointment only; English-language guides are available upon request—who want a chance to tap into Barragán’s brand of minimalism, which involved bold monochromism and a masterful use of light; striking horizontality and framing applied to windows, gardens, and views; a highly sui generis Catholic spirituality; and, not least of all, the architect’s bizarre need for control, in everything from what staircases guests might use to what records got played in different rooms.

When Berlin was divided, Checkpoint Charlie was the most famous of the border crossings between the eastern and western halves of the city. It was here that Allied soldiers registered before crossing over into the Soviet-controlled sectors. Thanks to its appearances in Cold War thrillers from Bond movies to John Le Carré novels, it has become a symbol of that era in the city’s, and world’s, history. A small museum nearby includes a replica of the guardhouse that once stood here.