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Panama’s extensive, sinuous coastline provides some of the world’s most delicious seafood. Options are infinite, especially at the capital city’s Mercado de Mariscos. The offering is downhome, traditional and absolutely scrumptious. Pick up something to cook later or just plop down at one of several in-market restaurants for instant gratification. Savoring your ceviche and an ice-cold brew as the market roils around you is pure Panama.

Restaurante Celele in Cartagena’s hip Getsemaní quarter sits right at the cutting edge of contemporary Colombian cuisine. Chefs Jaime Rodríguez and Sebastián Pinzón see research as part of their endeavor and have dedicated years to exploring the region’s flavors, especially in indigenous communities. The bottom line is a well-thought-out menu, beautiful presentation and a celebration of the local in a warm, welcoming ambience.

Always a crowd, but how could it be otherwise? Shore panoramas frame breathtaking nature, turquoise seas and sugary, white sand. Mighty close to the perfect beach, dreamy and hot, with great sightseeing opportunities. Keep eyes peeled for jumbo starfish and other marvelous creatures, now a main beach attraction. The shopping’s good, too, especially for artisanal handicrafts and dishware.

Petite, luxurious Villa Deevena is at the heart of nature in Playa Negra, Los Pargos. Its clean lines announce this is something different and the magical dishes that come from Chef Patrick Jamon’s kitchen have created a local sensation, with an emphasis on seafood, always fresh and locally sourced. Exuberant tropical tastes (with a dash of the French) add to a refined, never-mass-tourism vibe.

Cozy and comfortable, it’s hard to leave Pangas. The hours fly by here, where the Las Baulas estuary meets the Pacific, at wooden tables, right on the sand; or beneath marvelous, sparkle-lit trees in a setting that’s practically one with the surrounding nature. A tropical fusion menu makes the most of local bounty, featuring innumerable fruits, grass-fed beef, and locally caught seafood; fresh-prepared cocktails intensify the vibe. Surf-racks and showers available to those coming off the waves; reservations suggested.

Set tight in the jungles around Hotel Casa Chameleon, at Las Catalinas, the restaurant Sentido Norte is 45 minutes from the Guanacaste provincial capital, Liberia. A hilltop restaurant helmed by Costa Rican chef José López, it showcases a mix of local tastes and other modern classics, from sunrise until sunset daily. French toast with plantains, and ceviche punta penca (shrimp, octopus, and avocado) are current top orders; don’t miss the liquid enchantment on offer at the bar, perfect for sunsets, and aguas de sapo, a sweet, spiky pop made with guaro aguardiente.

Viñedos San Lucas is a new multi-use development fifteen minutes outside downtown. Its gracious, yet rustic hacienda vibe is attracting new neighbors plus locals and visitors to a complex that includes a quaint hotel and spa, two Mediterranean restaurants, one of the region’s finest wine cellars and even a polo ground. Vineyard excursions (don’t miss the lavender and olive groves) offer a glimpse of a Mexico few know; the mood is divinely bucolic. Time flies painlessly over wine and conversation, both outdoors and in.

Husband and wife Gil and Rebecca Gutiérrez run the ranch known as Zandunga, some twenty minutes from central San Miguel. Every Sunday—and only on Sunday—the family-friendly ranch opens its gates to visitors and guarantees fun, in everything from live jazz and blues to outdoor dining and dancing, plus impressive country-style buffets groaning beneath grilled meats, tacos and other regional delights. The gringos love it, but you’ll see locals and Mexican tourists there, too. A day in the country that won’t bust your budget.

As more and more sophisticated travelers have turned up in San Miguel de Allende, the culinary scene has evolved apace. The jewel-box-like Moxi, inside the edgy Hotel Matilda, is a mandatory for foodies (and delicious even if you just like eating) with dazzling takes on Mexican recipes by Chef Pancho Ibáñez, who relies on organic, locally-sourced ingredients. Fun fact: moxi is the Otomí word for “craving;” adventurous diners get it right away. Swing out for the tasting menu and its near-impossible dazzle.

American sommelier Brian Patterson, his wife, Jenn, and their massive Leonberger-Retriever mix, Bear (the Beartender!) are the consummate hosts at Lisbon’s newest, most interesting, and surely smallest wine bar. Located on pretty Praça das Flores in Principe Real, Patterson curates his all-natural wine list with a laser focus on small producers from around Portugal. He sources his finds on reconnaissance drinking missions around the country, including some of Portugal’s more underdog wine regions. His updated-daily chalkboard menu includes a half dozen or so offerings by the glass (€3.50-7) along with two batch cocktails, as well as intriguing bar snacks to accompany (his hummus is destination-worthy in and of itself). The bar doubles as a bottle shop; rightfully so, there is only room at the bar for about 11 provided everyone is sucking in their wine guts. File under: Wine Revelation.

Drink Kong is the neo-noir, Manga-meets-Blade Runner–inspired bar created by Rome’s Patrick Pistolesi. A labyrinth of dark-colored lounge spaces, with long bars, neon lights, and harlequin-patterned floors, Kong is both hang-out and experiment. Pistolesi, who has curated some of the city’s best bar menus and is one of the key players in Italy’s cocktail evolution, created an instinctive menu based only on flavors: bitter, sweet, dry. Either peruse the menu for a Kong signature cocktail like “Big Trouble in Oaxaca,” a spicy and slightly fruity tequila and mezcal drink or chat with Kong’s expert bartenders who can craft cocktails customized to your tastes. Or take a leap of faith in the Omakase Room, a Japanese-influenced wood-paneled room for private tastings in the omakase style—your drink will be whatever the bartender chooses for you.

To open this all-organic small-plates newcomer near Sé Cathedral, Chef António Galapito imported a caravan of culinary wizardry from the U.K.'s Taberna do Mercado (the London restaurant of Michelin-starred chef Nuno Mendes), including four members of the kitchen staff. The daily menu is an imaginative—challenging, at times—procession of flavor and fun. Standouts might include a charred purple broccoli with buckwheat in a tangy red pepper coulis; a black pork tenderloin with quinces and chocolate peppers; or a portobello mushroom ice cream with pearl barley, sea lettuce flakes, and pork-fat salted caramel (you read that right). Whatever’s on, it will surprise and dazzle even the most blasé of foodies while recalibrating your idea of what Portuguese cuisine is and can be.

Superstar chef José Avillez’s flagship dining destination is considered the country’s top restaurant. One of Lisbon’s Michelin two-starred affairs (the other is Alma) and fresh off a recent refurbishment, Belcanto is indeed the perfect place to enjoy Portugal’s rich bounty in the most wonderous, creative, and experimental of ways. The classic tasting menu (€165) nets you Avillez’s signature Garden of the Goose that Laid the Golden Eggs (egg, crunchy bread, and mushrooms), his most famous work of culinary art. More experimental is the Evolution menu (€185), where dishes such as sea bass with smoked avocado, pistachio oil, lime zest, and dashi push boundaries of tradition. It’s a tough choice, especially considering the classic menu ends with Avillez’s wicked cold citrus bomb of a dessert, Tangerine. Belcanto rang in at No. 42 on the coveted 2019 World’s 50 Best Restaurants list.

The Court, an off-the-radar lounge bar with front row seats to the Colosseum, is the perfect place to wind down in Rome. The bar overlooks the archaeological ruins of the Ludus Magnus (the site where the gladiators trained) and offers a view of sunset over the Colosseum, the world’s most amazing arena. The cocktails are the creation of mastermind Matteo Zed, one of Rome’s top bartenders, whose tasty Rising Sun (a gin, yuzu, and matcha cocktail) may well keep you at the bar until dawn.

Comprised of just 10 suites with distinctly different designs, Palácio Belmonte feels more like a dream vacation home than a hotel. The vibe is spot on, given the backstory: A Frenchman traveled to Lisbon looking for a vacation home in the Portuguese capital. He first saw the building from a taxi and thought to himself, “It has nine windows, just like my home in France. I’ll buy it.” It wasn’t until after purchasing the property that he actually set foot inside and saw just how enormous it was—far too large for him and his family. Thus, he set about remodeling the building (which was originally owned by a noble family in the 1400s) with the notion of converting it into a space for visitors.