Built in 1907 by the same architect who designed the National Theatre and Hallgrímskirkja church, Apotek is full of historical resonance. The Art Nouveau–style building was once the country’s largest edifice and served as the city’s primary pharmacy from 1930 to 1999, a distinction that gave the hotel its name when it opened in 2014. The property’s 45 rooms blend elements of the past while seamlessly incorporating modern design touches, employing neutral colors, parquet floors, and simple-but-refined furnishings to create a sense of calm; subway-tiled bathrooms with walk-in showers have a bright, clean look. You don’t have to wander far to enjoy one of the busiest watering holes in Reykjavik: Apotek Kitchen + Bar is a hot spot for artisan beverages, where cocktail “pharmacists” craft potions for every ailment. Bonus: Not only does it overlook the Austurvöllur park, it’s just around the corner from the Icelandic Punk Museum.