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Mount Pellegrino, which towers over the coast between Palermo and the beach of Mondello, is a popular day excursion from Palermo. The panoramic view from the top is breathtaking. And while you’re up there you can visit the sanctuary of Santa Rosalia, who is believed to have saved Palermo from a plague in the 1600s. She lived in a cave on the mountain until her death around 1160, and more than four centuries later hunters found remains that were thought to be hers. The plague in Palermo ended, it was believed, because her bones were finally given a proper Christian burial. This shrine was built around her cave to protect the site, and Santa Rosalia was named the patron saint of Palermo.

Historic Santo Domingo offers a unique look at how the New World was settled in the years following Christopher Columbus’s arrival in the Caribbean on his first voyage in 1492, as well as subsequent expeditions. The Colonial Zone sits along the Ozama River, where the settlement’s original layout, walls, forts and other buildings remain much as they were 500 years ago. With its wealth of colonial architecture, the area has not surprisingly been recognized by UNESCO as a World Heritage Site. Among the historic buildings is the first cathedral built in the Americas, the Basilica Cathedral of Santa María la Menor (also known as the Catedral Primada de América, recognizing its historic significance). The ornate church once housed the remains of Christopher Columbus until they were moved to the Columbus Lighthouse, in the eastern part of the city.

This stylish wine bar, bottle shop, and all-day restaurant is the brainchild of two food and wine world forces: Jessi Singh, the chef from San Francisco and New York City’s acclaimed Babu Ji, and James Beard Award–winning sommelier Rajat Parr. Opened this year, Bibi Ji, which takes its name from an Indian term of endearment, pays tribute to the women in the cofounders’ lives who cultivated their love for food and hospitality. The seafood-focused menu with Australian and Indian influences changes regularly, depending on what’s available at the Santa Barbara farmers’ market. Oysters are accompanied by pickled green mango butter, sea urchin is featured in the uni biryani dish with fried rice, and the seafood coconut curry can include prawns or vegetables. The presentation is almost so pretty you don’t want to disturb it, but let that moment pass and dig in. Pair your meal with any of the limited-run, small-keg draft beers; the rotating new beers in the beer fridge; wine from the bottle shop—or surrender to the experts and let them do the pairing for you. Whether you sit indoors or outside, the California spirit blends with Singh’s and Parr’s beloved India, making the restaurant what the owners call a “good-time place.”

At the northern end of the Malecón sits Cerro Santa Ana, the site where early settlers first established the city of Guayaquil. This area is today home to the neighborhood Barrio Las Peñas, known for its vividly colored houses that rise up the hill, bisected by a double-wide staircase lined with restaurants, bars and galleries. The summit has panoramic views across the city and up and down the river. To ascend even higher, climb to the top of the 18.5-meter (60-foot) blue-and-white lighthouse, built in 2001.

The establishment bears two names for a reason. Lenox is the front room, a restaurant chasing after that holy grail of U.S.-style diner food that’s just refined enough to appeal to the beautiful people (remember Max’s Kansas City?). Tables are tight and eavesdropping may be impossible to avoid, so watch what you say. Behind Lenox lies Parker, a larger (if just as crowded) space, home to live music, sexy lounge areas, and a long, shimmering bar whose staff is thoroughly up-to-date on the latest craft cocktails. What might first seem like a cliquey crowd opens up after a drink or two.

The city’s iconic wood-paneled Tram 28 rambles along a 4.3-mile route from Campo de Ourique to Praça Martim Moniz, navigating tight turns and steep inclines as it passes some of Lisbon’s most endearing attractions. Originally commissioned in the 1930s, these classic Remodelado trams were in fact enlisted for their ability to handle Lisbon’s hilly terrain. They can get painfully crowded—wait times can be outrageous in the high season—so catch an early ride (5:40 a.m. most weekdays, or 6:45 a.m. on Sundays) for unobstructed views of hilltop neighborhoods like Graça and the Alfama.

Listing Montreal’s best restaurants is nothing short of a feat; indeed, Montreal has the second largest number of restaurants per capita in all of North America, with a new establishment setting up shop every week or so. From Italian trattorias to izakayas, from hole-in-the-wall bagel shops to classic eateries and French brasseries, to trendy Nordic-inspired and hipster-run taco shops, there is no such thing as leaving Montreal hungry.

Alternative new venues underscore Hanoi’s status as the nation’s capital of understated hip. Hanoi has pop-up cafés in the homes of artists, cafés that strike the right balance between quality coffee and youthful atmosphere. Also, tucked-away you will find Hanoi’s bars and music venues purveying heady cocktails, and soundtracks covering all bases from Thai funk to hip-hop beats sampled from scratchy vintage Vietnamese records.

Some attribute Hoi An’s plethora of tailor shops to its history as a center for the silk trade, even though the bespoke clothing boom is a recent one. Others maintain that the phenomenon comes from a Vietnamese propensity for copycat businesses. Either way, the ancient town has established itself as the place to get clothes made economically in Southeast Asia. If getting some new threads is on your Vietnam wish list, there are several reputable tailors and boutiques in town.

There’s loads to do if you have 48 hours in Nairobi. With boutique shops, atmospheric restaurants, and plenty of live music, it’s not hard to see why Nairobi is developing a reputation as one of the coolest cities in the world. There are new skyscrapers, bars, and apartments sprouting up constantly, and no, it’s not the prettiest city ever. But Nairobi’s residents are friendly, motivated, and enthusiastic about their home town, and there’s far more to Nairobi than first impressions might reveal.

Located in Santa Teresa, Aprazível is foodie heaven in a welcoming atmosphere. The name says it all—aprazível is Portuguese for pleasant or pleasurable—a meaning that becomes clear as soon as you take in its intensely orange, intensely Rio sunset views. The kitchen calls the food roots cuisine: moqueca (fish stew), hearts of palm, Amazon fishes, coconut rice, plus excellent steaks and chops. Naturally there are typically Rio desserts, as well as tropical drinks and artisanal beers. The Brazilians love it, and out-of-towners do too; if you add it all up, you’ve got the quintessential Carioca experience.

English explorer and draftsman Frederick Catherwood and American adventurer John Lloyd Stephens were the first foreigners to rediscover Copán and numerous other Maya cities. Catherwood’s extraordinary lithographs, on view at the Catherwood House Museum, portray those monuments as they appeared when the pair first witnessed them; the institution’s Belle Époque setting transports visitors to Catherwood’s day and conjures the wonder he experienced as he wandered the Maya world of Mexico and Central America. A coffee enjoyed in the courtyard and a poke through the elegant gift shop are icing on the cake.

Why we love it: A sprawling retreat offering high design and a beachfront location

The Highlights:

• Guest rooms with private plunge pools or whirlpools
• The only Thalasso therapy wellness spa in Baja
• Five separate pools, plus 4,000 square feet of beachfront

The Review
Though the Baja Peninsula has welcomed a slew of luxury properties over the past few years, it seems the 128-room Solaz is only in competition with itself. First, there are the sophisticated stone-and-wood interiors, which balance high-tech details (remote controlled lighting) and luxe amenities (outdoor showers, private plunge pools) with locally sourced decor and wall sculptures by Mexican artist César López Negrete.

Guests even have the option to add personal butler service, which can arrange everything from swimming with whale sharks to ordering a bottle of local wine from the property’s wine cellar. Outdoors, the landscaping features endemic desert plants like agave and cacti, with a hardly a palm tree in sight.

Then there’s the spa, a 10,000-square-foot refuge that features the region’s only Thalasso therapy seawater treatments and a Himalayan salt igloo. Five pools (including two sleek infinity ones that overlook the Sea of Cortez), four dining outlets (a Mexican breakfast spot, a seafood restaurant, a poolside cafe, and a coffee lounge), a beachfront fitness center, and 4,000 square feet of white-sand shoreline complete the desert dream.

Never underestimate the power of shocking pink. The intimate but lively dining room at Dulce Patria—the smash hit by celebrity chef Martha Ortiz—feels not unlike a stage set. Soon after 2 p.m., it starts to fill with high-powered ladies-who-lunch types, cooing over a menu of updated Mexican classics with extravagant, architectural presentations that are at least half the fun. That said, chef Ortiz’s flavorful sculptures really deliver: Tastes are delicate, authentic, and quite delicious. The well-balanced offering presents ample choices without overwhelming, in favorites like the corn-kernel soup, a full portfolio of quesadillas, duck mole, and an extravagant dessert list (gelatin lovers rejoice) that really does drive home the dulce part. A recent seating included telenovela stars and a former Señor Presidente. And who knew there were so many edible flowers?

According to Islamic tradition, only God can create images of holy beings, including angels and prophets. Therefore, when the Ottomans converted Chora Church into a mosque in the 16th century, they covered the 14th-century Byzantine mosaics and frescoes depicting the life of Christ and Mother Mary. Hidden behind wooden shutters were some of the finest mosaics in the world, which were restored following World War II and can now be viewed in all their glory.