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The Milan Cathedral, or Duomo, occupies a site that’s been holy since the time of the Romans, but it wasn’t until the early 19th century when the finishing touches were finally placed on this massive building. The Duomo is the fifth largest cathedral in the world and one of the top tourist sites in the northern Italian city. Entrance is free, but a small fee is requested if you wish to take photos. Inside the church is even more magnificent then the outside, with scores of shrines and altars dedicated to saints and notable Milanese. During the Christmas holidays the city’s night market takes up residence next to the cathedral, adding one more reason to visit this central site.

Seoul has been slow to the craft-beer craze due to strict government regulations and taxes. In recent years, however, a small number of new local breweries have been leaving their mark on the city. One such trailblazer is Magpie Brewing Co., opened in 2012. Easily identifiable by its cute bird logo, the brewery has become a favorite of thirsty hipsters and expats for creative beers made with interesting ingredients and balanced flavors. You’ll find both seasonal and flagship beers, ranging from IPAs and pale ales to porters and wheat brews, at the two laid-back locations in Noksapyeong and Hongdae. To complement the beverages, the brewery offers American-style pizza—a food that’s not easily found in Korea.

On the central coast north of Valparaíso, the beach resort town of Concón is popular with Chileans for its boardwalk, great restaurants, and, most of all, the 52 protected acres of monumental sand dunes that cascade down from high bluffs all the way to the sea. In addition to hikers, the dunes draw sandboarders who climb to the top, wax their rented boards by rubbing them with candle stubs, and then slide or sled down the slopes to the sound of the sea lions barking in the waters below.

At three times the size of the Big Island of Hawaii, this is South America’s largest island. Split almost equally between Argentina and Chile, Isla Grande de Tierra del Fuego is divided from the mainland by the legendary Strait of Magellan that saved sailors the long, treacherous route around Cape Horn. The Argentine town of Ushuaia, on the island’s southern coast, is a launching point for journeys that take travelers through the Strait of Magellan and past the glacier-covered 2,438-meter-high (7,999-foot-high) Mount Darwin off of the Beagle Channel.

A beautiful 15,000-acre park in Israel’s Negev Desert, north of Eilat, Timna Park offers visitors spectacular views of the arid desert landscape and ancient geological formations. One highlight is the copper mine at Mount Timna, which scientists and historians consider to be the world’s very first. At least 6,000 years ago, the area was mined by ancient Egyptians by order of their pharaoh, as well as by Israelites under the rule of King Solomon. Tours of the park, including highly recommended bike tours, are available daily, as is zip-lining, pedal-boating on the artifical lake, and the Timna Safari Shuttle, which leaves from Eilat.

Many temptations are under one roof at the Langham, New York, Fifth Avenue. This polished hotel bucks the trend of tiny Midtown hotel rooms with spaces that begin at 420 square feet and stretch up to apartment-style accommodations with full kitchens—an ideal setup for families. The style is modern and refined, from the sweeping staircase that connects the lobby to the Michelin-rated Ai Fiori restaurant of chef Michael White on the second floor. The hotel doubles as an art gallery for the work of American artist Alex Katz, whose bold figurative paintings hang on the walls throughout the hotel. There’s also Chuan Body + Soul, a day spa based on the principles of Chinese Medicine.

Cartagena’s Museum of Modern Art (Museo de Arte Moderno de Cartagena) contains a somewhat modest collection of about 300 works, most of which are paintings or sculptures donated by Colombian and other Latin American artists, including Enrique Grau and Oswaldo Vigas. The colonial-era building housing the museum is located within the walls of the historic part of the city; as such, it can easily be included in a morning’s or afternoon’s explorations, whether independent or guided.

It’s fun to imagine that Xcalak, a sleepy coastal village south of Mahahual on Mexico’s Costa Maya, is what the entire Caribbean coast of Mexico looked like before the creation of the Cancún megaresort in the 70s. No Spring breakers, no cruise ships, no thumping beachside clubs, no big hotels. Just white sand and palapas, palm trees and pelicans, hammocks and fishing boats. Just you in secluded relaxation away from it all. Several clean and basic hotels are located on the old coast road and fresh, cheap seafood is abundant at local favorite Toby’s. Dive and snorkel trips can be arranged at XTC Dive Center (www.xtcdivecenter.com), located about 300m north of town.

Dieppe Bay is ringed by black sand—a reminder that St. Kitts was formed by volcanoes. It’s also the site of the first European settlement in the eastern Caribbean, a French colony established in 1538 that was destroyed by the Spanish just two weeks after its founding. Beyond its historic significance, however, Dieppe Bay is simply a peaceful, palm-lined beach on the north end of the island. An offshore reef keeps the water calm for swimming and snorkeling, and Arthur’s restaurant is nearby for when you’re craving some fresh fish and vegetables.

Cozy, romantic, and right on the beach, this Sanibel restaurant is perfect for a special-occasion dinner. Book a table for the hour leading up to sunset, then linger over New American cuisine like lobster tempura, blue crab cakes, and roasted oysters with chorizo. Also available are meat-centric dishes like short ribs, grilled filet mignon, and Hudson Valley foie gras.

While the waters of the massive Great Salt Lake are too salty to sustain anything more than algae, brine shrimp, and brine flies, the wetlands on its north and east shores are critical habitats for millions of migratory birds, making it a top-notch bird-watching destination. There are three state parks adjacent to the lake, including the Great Salt Lake Marina, where you can launch sailboats and kayaks. And if the water level is low enough, you’ll be able to see the famous Spiral Jetty, a 1,500-foot-long art installation made of salt-encrusted basalt slabs.

Set on 4,200 secluded acres of hillocks, ponds, and gardens at the foot of the Tennessee Smoky Mountains, this award-winning resort, a member of the prestigious Relais & Châteaux brand, is awash in genteel luxury, from its splendid spa to its exquisitely appointed rooms, suites, and cottages. But make no mistake, the family-owned property takes the “farm” in its name to heart: Its James Beard Award–winning restaurant, The Barn, as well as the more informal Dogwood restaurant, were early leaders in the farm-to-table movement, welcoming guests who come to pay homage to the inn’s self-described foothills cuisine.

In addition to several gardeners, the farm employs its own butcher, cheese maker, and beekeeper, along with a preservationist who makes pickles, jams, and jellies. The staff raise their own sheep, pigs, and chickens, and forage the land for mushrooms, berries, ramps, wild crab apples, and muscadines—which you’ll share at the table with other guests (all meals are included in your stay). Thankfully, a roster of on-site activities—including cycling, wakeboarding, archery, paddleboarding, hiking, fly-fishing, swimming, tennis, and golf—allow you to indulge without feeling guilty.

At the beginning of the 20th century, a physics professor in Massachusetts inherited a ton of money. He promptly headed for the South Pacific, settling there and founding what’s now the Harrison Smith Botanical Garden. Maybe Smith had a slight Noah complex: He brought in plants from around the world, which means an African flower might sit next to a South American fern. The problem is that he inadvertently killed off the native plants with his imports. Still, the garden is a lovely spot to wander around, a sampler box of world botany.

In 1934, architect Luis Barragán won a contest put on by the city of Guadalajara to design a park on former prison land, creating a gateway to the city center. Together with his engineer brother, Barragán based his design on functionalist, Art Deco, and California modernist styles, incorporating elements of red and yellow as a nod to French 1930s design. Although the park (originally named Parque Revolución but now referred to as Parque Rio, or Red Park) has undergone significant changes over the years, certain elements—the red-and-yellow benches, the kiosk, the fountain, and the mashup of 1930s and ’40s architectural styles that would come to define Barragán’s later work—are still intact.

The Key West Shipwreck Museum transports visitors back to 1856, when the young city’s port had more than 100 ships passing through daily. Because of the coral reefs, shipwrecks were common at the time and salvage became a thriving business. At the museum, visitors will meet an actor portraying Asa Tift, an actual Key West citizen whose family made a good living salvaging, or saving, crew, passengers, and cargo from ships that were wrecked on the reefs. He’ll tell the stories of the many wrecks and recoveries of Tift’s time. The museum’s immersive experience includes films and historic artifacts, including the wreckage of the Isaac Allerton, which sank off the coast in 1895.