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Cartagena’s Museum of Modern Art (Museo de Arte Moderno de Cartagena) contains a somewhat modest collection of about 300 works, most of which are paintings or sculptures donated by Colombian and other Latin American artists, including Enrique Grau and Oswaldo Vigas. The colonial-era building housing the museum is located within the walls of the historic part of the city; as such, it can easily be included in a morning’s or afternoon’s explorations, whether independent or guided.

The Natural History Museum houses some 35 million specimens and artifacts spanning 4.5 billion years in history. But it isn’t just what’s inside this structure that’s historic: The main building itself dates all the way back to 1913, when a Sunday school teacher—upset by the seemingly unstoppable influx of saloons, gambling locales, and other centers of vice—convinced the city to develop what’s now called Exposition Park. Fast-forward to the present, and the Natural History Museum is more than just a place to see weird animal bones and models of long-extinct Homo sapiens. The museum hosts plenty of public events throughout the year, including mini nature festivals, evening cocktail parties, and opportunities for community science. The neighboring California Science Center is a draw for the kiddos, and Exposition Park as a whole is occasionally leased out for large-scale music fests.

With two hiking trails ascending 1,280 feet to its peak, Camelback Mountain is a great option for nature-fiends who like a challenge. Both the Echo Canyon and Cholla trails exceed a mile in length and are accented with steep grades. Average hiking times range from 1.5 to 3 hours round-trip, so pack accordingly and bring enough water.

Don’t miss Parque del Retiro—a stunning area complete with a lake, playgrounds, gardens, and fountains. It’s the perfect public space where anyone can enjoy the day by taking a walk, playing a game, going on a boat ride, or exploring to your heart’s content.

The crumbling architecture of Stone Town is a UNESCO World Heritage site, and the town’s carved doors are one of its most recognizable features. I spent a lot of time searching for the door of Swahili merchant Tippu Tip, a notorious 19th-century slave and ivory trader who grew fabulously wealthy from his exploits in the interior of Africa. He showcased his wealth by slapping Stone Town’s most elaborately carved door on the front of his mansion in the mysteriously named Suicide Alley. If you can find Suicide Alley (it’s unmarked, near the Shangani Post Office in Stown Town), keep your eyes on the ground: the alternating black-and-white tiles of Tippu Tip’s front stoop might be the first thing you see. The house is now inhabited by several families, so be respectful when taking pictures and exploring the area.

Cozy, romantic, and right on the beach, this Sanibel restaurant is perfect for a special-occasion dinner. Book a table for the hour leading up to sunset, then linger over New American cuisine like lobster tempura, blue crab cakes, and roasted oysters with chorizo. Also available are meat-centric dishes like short ribs, grilled filet mignon, and Hudson Valley foie gras.

Many temptations are under one roof at the Langham, New York, Fifth Avenue. This polished hotel bucks the trend of tiny Midtown hotel rooms with spaces that begin at 420 square feet and stretch up to apartment-style accommodations with full kitchens—an ideal setup for families. The style is modern and refined, from the sweeping staircase that connects the lobby to the Michelin-rated Ai Fiori restaurant of chef Michael White on the second floor. The hotel doubles as an art gallery for the work of American artist Alex Katz, whose bold figurative paintings hang on the walls throughout the hotel. There’s also Chuan Body + Soul, a day spa based on the principles of Chinese Medicine.

Less than an hour from Guadalajara, Lake Chapala—Mexico’s largest lake—offers a relaxing respite from the big city. Visitors can enjoy drinks or a meal at one of the many restaurants on the pier, watch the sunset from a sandy beach, or rent a boat to the Island of Scorpions for a different view. There are plenty of boutique hotels around the lake should you be interested in an overnight stay.

To get to Lake Chapala, catch a direct bus—they leave every 30 minutes from Guadalajara’s Old Bus Central. The air-conditioned ride through the mountains of Jalisco takes somewhere between 45 minutes and an hour, depending on traffic, and costs approximately US$5 for a round-trip ticket. Once you arrive at the Chapala bus station, the lake is about a 10-minute walk away on the main street.

At the beginning of the 20th century, a physics professor in Massachusetts inherited a ton of money. He promptly headed for the South Pacific, settling there and founding what’s now the Harrison Smith Botanical Garden. Maybe Smith had a slight Noah complex: He brought in plants from around the world, which means an African flower might sit next to a South American fern. The problem is that he inadvertently killed off the native plants with his imports. Still, the garden is a lovely spot to wander around, a sampler box of world botany.

A visit to the incredible 365-island archipelago (also called the San Blas Islands) within the communal lands of the Guna Yala indigenous nation provides some extraordinary seaside experiences. The islands making up the outer archipelago are unspoiled and feature gorgeous white-sand beaches, turquoise seas, and a one-of-a-kind encounter with Guna culture. Visitors lodge in natural-material huts (cane walls and interwoven palm-frond roofs) or—if you’re in the mood—sleep under the stars in palm-strung hammocks. Local women sport colorful dress made in the style known as mola, a traditional Gula artisanal weaving technique. A highway was built several years back that lets you travel from Panama City to Puerto de Cartí in as few as two hours.

The red brick building that houses DeSoto Central Market has lived many lives over the course of its 90-plus years—first as a car dealership, then an antiques shop, and at one point, an advertising firm. Today, the sprawling structure is a market and gathering space where locals go for oysters, burgers, Mexican-Asian fusion spreads, community events, and more. DeSoto is both a retail beacon to the modern-day consumer (there’s a cold-pressed juice bar and a kiosk selling ethically sourced stone jewelry, for instance) as well as a stunning reflection of Phoenix history, complete with exposed brick walls and rustic beams overhead.

To the northwest of central Copenhagen, much-photographed (though less frequently visited) Grundtvigs Kirke is notable as a rare example of a church constructed in the expressionist style. Architect Peder Vilhelm Jensen-Klint won a design competition for the church commission in 1913, but World War I delayed construction until 1921, and the structure was not completed until 1940. (Jensen-Klint was also responsible for the surrounding residential development.) Grundtvig’s monumental and severe exterior was inspired by traditional Danish churches, while the soaring interior is filled with light that pours through the clear windows on sunny days and illuminates the pale yellow bricks. A bit off the beaten path, the church is about a 20-minute bike ride from the city center. The trip takes longer if you use public transportation, so do as the Danes do and hop on a bike.

Two of Manila’s most famous churches can be found in close proximity to each other within the historic walled city of Intramuros. The 16th-century San Agustin Church, a UNESCO World Heritage Site, is the oldest church in the Philippines and was the only building in Intramuros to survive heavy bombing in World War II. It boasts an impressive interior with trompe l’oeil effects, a Baroque pulpit and a majestic pipe organ, and the museum houses treasures of Old Manila. A few blocks away, the Manila Cathedral, restored many times since the original version was built 450 years ago, hosts religious artworks and sacred relics and was visited by Pope Francis in 2015.

Formerly the headquarters of the U.S. District Court in these parts, the low-slung brick building on the central waterfront now houses the island’s best handicrafts display. The maze features 150 artisans selling everything from handmade dolls and quilts to note cards and wooden serving items. There are also food vendors on site.

The Monsignor Romero Center, located on the grounds of the Central American University, has a museum that honors the victims and heroes of the Salvadoran civil war. While much of the material—including albums full of disturbing photos—may not be appropriate for children, the center, when considered alongside other historical sites that remember this era, helps adult visitors understand part of the bigger picture of El Salvador’s recent past.