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From hipster to haute couture and small palazzo to skyrises, Milan’s unique neighborhoods have unforgettable personalities that make the city an incredible adventure at every metro stop. One-of-a-kind shops, fabulous street art, clever galleries, trendy restaurants, and vibrant nightlife are the essential characters that define Milan’s neighborhoods and contribute to the overall vibe of Milan as a city not to be overlooked.

Ask most Hanoians, and they’ll tell you that the best place to eat in the capital is on the street or at one of the city’s many eateries lit by strip lights. But for those wanting a more relaxed and extended dining experience, the city also offers a decent number of pleasant, yet authentic, restaurants.

A night out in Istanbul is rife with possibilities. For a traditional Turkish experience, linger at a teahouse or an atmospheric nargile bar; for a more contemporary take, follow the cool kids to lively cocktail spots in Nisantasi or Karakoy. There are wine bars for sampling local vintages, rooftops for savoring a view of the Bosphorus, and streets known for their outdoor cafes and roving musicians.

Istanbul has a rocking nightlife that spans both continents and all hours of the evening—and early morning. While options for wild nights are limited in the tourism precinct of Sultanahmet, the beats pick up across the Golden Horn in the Beyoğlu District with rock, alternative, and world music venues along the side streets off Istiklal Caddesi. For supper clubs and VIP style, head to Ortaköy or Kuruçeşme to party by the Bosporus.

The Grand Bazaar looms large as Istanbul’s most renowned shopping destination, with 61 covered streets where you can haggle for handwoven carpets, fine jewelry, spices, and many more Turkish souvenirs. It’s not the only market worth browsing, and you’ll find everything from contemporary shopping malls to independent boutiques vying for your attention.

Give yourself a break from Barcelona’s noise and traffic and travel to another time and place: life as lived in Catalonia’s smaller villages and historic old towns. Stroll medieval bridges, hike around stone houses that hang onto green hills for dear life, and enjoy a breather from the crowded streets of Barcelona. Foodies can shop in tiny artisan shops for charcuterie, cheeses and bread or eat traditional and nouvelle cuisine made from seasonal and locally sourced ingredients

Greeks, especially Athenians, are high-spirited partiers, and don’t stop till they get enough. For those seeking glamour it’s fun to sip cocktails on a rooftop bar, but it’s just as fun to dance in a grungy music venue. Wander near the Technopolis in Gazi or the clubs near the sea during summer, when the party simply spills out onto the streets. Start late, and pace yourself until sunrise, which is when most locals only begin to think about going home.

Wander the streets of the medina, stopping in spice shops and honey souks, and visiting the quarters where artisans make copper pots or intricately scrolled window screens, or puzzle together the local tile work. The local markets and shops can convert the biggest skeptic into a diehard shopper.

The foods of Israel—from falafel on the street, to fish just caught from the Mediterranean, to a meal made by an internationally known chef—has one thing in common: Freshness. Israeli cuisine reflects its surroundings (date syrup-infused tahini, for instance). Rare is the traveler who returns home from Tel Aviv or Jerusalem lukewarm about the food.

The Franciscan Garden is delightful public space just off the busy Wenceslas Square on the site of a former Franciscan monastery and dates back to the medieval period. Head through the Světozor passage from Vodičkova street or the Alfa passage from Wenceslas Square. Find a seat on one of the benches — a great spot for people watching —and admire the climbing roses in bloom or the Church of Our Lady of the Snows. If you have children let them enjoy the playground and an ice cream while you sit back and take a breather under the trees.

Switzerland’s largest city mixes urban pleasures with lots of natures, most notably Lake Zurich. The Swissôtel’s location near the train station is convenient for business travelers, while 25 Hours Hotel Zurich West offers a business lounge alongside playful local touches such as a kiosk selling Freitag bags. For 5-star service, book the Baur au Lac, set along the lakeshore and close to Zurich’s famous shopping street Bahnhofstrasse. Escape to the fairytale-like Dolder Grand for a true splurge.

After decades of rule by innocuous lagers, a small revolution is brewing in Beijing’s beer scene, with a handful of small-scale brew operations popping up over the past few years. Great Leap is among them and brings together foreign beer makers with local ingredients in a way that doesn’t make “East meets West” sound cliché.

Take the popular Honey Ma Gold Ale. It has peppercorns from Sichuan, in central China, and Shandong date honey from the coast. Meanwhile, Little General IPA uses Chinese hops, while Danshan Wheat Beer includes black tea from Fujian. All fun to try. Beers at Great Leap start at ¥25 for a pour of Pale Ale No. 6. Great Leap’s flagship brewery and pub, on Xinzhong Street, can handle everything from large parties to single imbibers, offers views of the brewing equipment behind a glass wall, and has a good range of bar food, including a tasty burger and fries at ¥40. Order it and you are almost sure to get one last pint.

When Charleston’s Blind Tiger opened in the late 1980s—long after Prohibition ended—its name, a phrase synonymous with “speakeasy,” lent the Broad Street bar a delightfully naughty air. Not that the joint needs more atmosphere. The building, which dates back to 1803, has the vibe of an old Irish bar, with big front windows, dark wood, the damp smell of years of spilled beer. But walk through the doors in back and you’ll find a tree-shaded, sun-dappled patio full of architectural ruins and kitted out with a few firepits for cool evenings. That handy backyard bar means you can stay in the fresh air and not venture inside for refills. Alas, the blissful al fresco scene is slightly marred by the inclusion of a television over the bar. (With college football enjoying nearly the same status of religion in the Holy City, only the fanciest cocktail bars can avoid having the game on in these parts).

The tram gives Portland visitors stunning views of the city, river, and mountains beyond. Grab the streetcar from downtown out to the waterfront. You’re delivered to the lower terminal for the three-minute ride carrying you 3,300 feet at 20 MPH to the upper terminal at OHSU. Linger for photo ops then head back down to explore. If it’s nice, skip the streetcar and walk back along the river. Daily workout, check. Roundtrip cost: $4. At the lower terminal, the Daily Cafe is an easy find in the atrium of the OHSU Clinical building as you disembark the pill-shaped car, built with precision by the Swiss. Head for the river and stroll along the shore in any weather. Double back along SW Bond Ave and consider lunch at Bambuza Vietnamese Bistro. Check out the pricey high-rise condos on the market in the real estate office windows, then relax in one of the pocket parks to people watch. It snows in Portland. A couple of times a winter, even downtown gets dusted and it’s a huge mess. I’ve dreamed about getting my ski gear on, grabbing my boards and heading for the PDX Tram at the South Waterfront. I’d casually climb aboard with the patients and medical folks heading up to “Pill Hill” and blow their minds.

AFAR chose a destination at random—by literally spinning a globe—and sent comedian Jorma Taccone on a spontaneous journey to Nairobi, Kenya.