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Gonçalo Alves and his wife, Marta Fonseca, spent eight years turning an abandoned chicken farm on Portugal’s wild Costa de Prata into their dream retreat. “We wanted a big house to share with people,” says Alves. Their hotel, located a 45-minute drive north of Lisbon, is a whimsical escape with a hippie vibe. Each night Alves and Fonseca invite guests to join them for wine and traditional folk music around a bonfire. The architecture is modern, but the interiors have a fashionable flea-market feel. Inside the 10 rooms and four villas you’ll find bedding, rugs, and light fixtures from Morocco and India, driftwood-frame beds, and fireplaces that hang from the ceiling. Doubles from $345. 351/2-6193- 6340. This appeared in the October 2013 issue.

Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

This perennially popular bakery and sandwich spot can feel somewhat out of place. With its cozy atmosphere in a plant-filled space, and its menu of warm panini, delicious sandwiches on artisanal breads, generous salads, and perfectly executed pastries, it is the sort of restaurant you’d expect to find in one of Montréal’s cooler neighborhoods. Instead, it’s in the heart of Old Montréal. That is a definite plus for travelers visiting the city’s historic sights. It also means, however, that there is a lunch-hour rush when nearby office workers vie for tables. If you can plan on an early or late lunch—you’re on vacation, after all—you can avoid the worst of the crowd. Olive et Gourmando is open from 9 a.m. to 5 p.m., so if you are looking for a place for dinner, the same owners are behind the new Foxy (in the Griffintown neighborhood), which is quickly proving as popular as their first restaurant.

In a city known for its breakfast tacos, it can be hard to decide where to start your day. One place that will never disappoint, however, is La Villita Cafe. The options here are simple—think bean and cheese, potato and egg, and chorizo and egg—but everything is delicious, especially the brisket and egg taco. When you’re done eating, check out the neighboring La Villita art community, which provides a window into San Antonio’s diverse past.

A clifftop eco-hotel surrounded by 50 barely touched acres on the bucolic North Kohala coast, Hawaii Island Retreat feels as far away as it gets. There are no TVs in the guest rooms, no air-con, and Wi-Fi only in certain spots. Solar and wind power provide all the electricity, while much of the fruit and vegetables are grown right on the property. Resident goats and bees supply the cheese and honey. The inn has 20 simply-furnished bedrooms in the main house, overlooking groves of cedar and pine trees, plus seven yurts a stone’s throw away, so it’s possible—likely even—that a guest might spend days here and rarely see another soul. The owners, a local spa therapist and natural healer and her physician husband, opened the property in 2009 with the express purpose of creating a wellness-focused retreat, which is why guests can sign up for classes in yoga, tai chi, and meditation, as well as facials and massages. Outdoor massage tables, placed under a tent, overlook a deep green valley. There’s also a mediation rock. So health-minded is this little retreat that it’s become a popular spot for guests recovering from serious illness or simply in search of a detox. Various packages have a wellness or spiritual theme.

A maze of narrow medieval streets wind up and down this village perched along the Grande Corniche. The ruins of a château are now an exotic garden, and the 18th-century neoclassical Notre Dame of the Assumption church is a national monument. Spectacular views inspire artists and artisans, and their galleries fill the village. Exceptional restaurants like the Château Eza are happy to welcome guests for a drink or a Michelin-starred meal as they relax and savor the scenery.

You’ve likely seen the main attraction of Tulum in a travel ad, a postcard, or a friend’s Instagram feed, but there’s still nothing like witnessing first hand the only Maya site that overlooks the Caribbean Sea. Standing before the 13th-century structures will leave you feeling awed by the Maya’s archaeological achievement and its resilience—still standing after being hundreds of years of being buffeted by salty water and wind. True, it’s the main attraction here, but it’s not the only one. With a quirky backstory and a lot of international press, more and more foodies are making their way to Hartwood, a restaurant that lacks electricity. The chef prepares all dishes—made with local ingredients—on an open fire.

This is the best way to explore Portland’s budding dispensary scene. At Serra Modern Druggist’s flagship downtown location, you’ll get a one-on-one walkthrough of edibles, flower, and every other form of cannabis product imaginable. The space screams high-end retail: glass, white oak, marble, white walls, succulents and plenty of branded items. Entry is limited so that customers receive one-on-one service when they enter the store. Snag a set of “feel all the feelings” matches and prepare for a learning session with a knowledgeable docent. The overall effect is calming, as well as a fascinating window into what legalized cannabis stores will look like as they spread to other parts of the United States.

The red-gravel paths that wind among 6,000 plant species, past a babbling stream, and into deeply shaded areas may make you forget you’re in the center of a loud, bustling city. That said, many visitors don’t know that the Botanical Garden includes a small butterfly garden. It’s closed during the week, but you can still peek over a low wall to watch some 50 butterfly species flit about their business. And for one glorious hour, from noon to 1 p.m. on Saturdays, the gate is thrown open and the public is free to walk sunny paths among shoulder-high flowering hedges as colorful, flirtatious butterflies alight on amused visitors’ heads, shoulders, and arms.

You’ll never sleep anywhere closer to Machu Picchu than Belmond Sanctuary Lodge—it’s adjacent to the site entrance, and the only hotel on the mountain. In fact, the lodge is built on the former staging area for American explorer Hiram Bingham, who rediscovered the “Lost City of the Incas” in 1911. You’ll pay a pretty penny but consider the price a once-in-a-lifetime splurge. If you arrive the day before your visit to Macchu Picchu on the bus up from Aguas Calientes, you can be at the gates right when they open at 5 a.m. and get a head start on most of the crowds—and the sunrise. And if you’re coming off a days-long hike on the Inca Trail, the spacious showers and plush robes will be the best you’ve ever experienced.

There are only 31 rooms here, some with terraces and mountain views but all with exquisitely comfortable beds and marble bathrooms. The light-filled restaurant—only open to guests—serves both international and Peruvian dishes, and the bar is a great place to enjoy a pisco sour after a day of exploring the ruins. If you really want to stay in style, consider arriving by the elegantly restored Belmond Hiram Bingham train from Cuzco—the hotel offers packages.

Ancient Hawaiians believed their souls would leap into the spirit world from this lava shoreline on the western tip of Oahu. These days, people jump off here in gliders instead, soaking up views of the Waiʻanae coast to the south, Mokuleʻia to the north—and the glorious, denim-blue Pacific stretching from here to eternity. Take a 5.4-mile round-trip hike and check out the albatross sanctuary on Kaʻena’s wild coastal acreage (free to visit). Keep an eye out for monk seals, one of the world’s most endangered species, found only in Hawaii. Watch for their silvery-gray sausage shapes as they lounge on the beach, but give them space. Always retreat if a seal awakes, vocalizes, shies away, or tries to shield a pup.

The understated and modest villas at the Hoshinoya Taketomi Island resort are a far cry from the characterless concrete and stucco of many beach resorts, but then again, this is Japan, where tradition and elegant simplicity are standard. The island of Taketomi prohibits modern buildings and encourages the traditional practices of red-tiled roofs and gukku stone walls with embedded talismans. Accommodations are either Japanese-style with tatami mats and futons, or more western with wood floors and modern furniture; all have deep soaking tubs, private gardens, and floor-to-ceiling windows that can be fully opened to let in the outdoors. The restaurant serves nouvelle French cuisine featuring island seafood and local ingredients, and the lounge encourages guests to unwind with a beverage and a book. For more active stays, the swimming pool is heated and shaded by banyan trees, and guests may borrow a bicycle to explore the island’s white coral sand beaches and watch the sun rise and set from the observation deck. The resort is reached by ferry and a shuttle from Ishigaki port, and visitors get around the island by water buffalo cart rather than car.

On Palermo’s western side, the Zisa Castle was built in the 12th century by Arab craftsmen as a summer retreat for King William I of Sicily. It’s now a UNESCO World Heritage Site, with handsome windows overlooking the gardens. The main hall, called the Fountain Room, has a distinctive Arabic-style vaulted ceiling with muqarnas—adornments that resemble honeycombs. The upstairs rooms hold a range of artifacts, including Anna’s Tombstone, a grave marker whose inscription is repeated in four languages: Hebrew, Latin, Greek and Arabic.

The largely French-inspired menu at Republique has more than a few surprises on it, like the generous selection of oysters and kanpachi crudo in Thai green curry and peanuts. The high ceilings, walls of windows, and loads of natural light make the atmosphere ideal, as the omnipresent line outside suggests. The grilled octopus salad—made with cabbage, Santa Barbara pistachios, chile, citrus, and lime—is a must. Brunch, however, is the real draw. The brioche French toast is doused in Vermont maple syrup; pupusas come with Oaxacan cheese, avocado, a fried egg, and roasted poblano; and the kimchi fried rice is dished up with beef short ribs and eggs.

With soaring arches, stained-glass windows, and details carved from stone imported from France, Bermuda’s Anglican cathedral is a bit of Gothic grandeur in the heart of Hamilton. Scottish architect William Hay was responsible for the design and construction of the grand building. After two fires—one of them a case of arson—the edifice was officially consecrated in 1911. Climb the bell tower’s 155 stairs for panoramic views that stretch from the city to the Royal Naval Dockyard and the north shore.