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Why we love it: A grande dame of the Gulf Coast with a glamorous history and luxurious amenities to match

The Highlights:
- A spot on the National Register of Historic Places
- Family-friendly amenities like watersport rentals and a kids’ club
- A stunning spa with a rooftop terrace overlooking the beach

The Review:
Known to many as the Pink Palace, The Don CeSar is a beachfront icon. Real estate scion Thomas Rowe built the hotel in 1928 as a tribute to his lost love, turning it into a popular destination for such acclaimed Gatsby era figures as Clarence Darrow and F. Scott Fitzgerald. Following his death in 1940, the U.S. Army purchased the hotel to be used as a hospital and convalescent center for airmen returning from World War II, but let it fall into disrepair after the war. Thanks to locals, The Don was saved from the wrecking ball in 1971, reopened as a full-service resort in 1973, and added to the National Register of Historic Places just a year later.

Today, the hotel continues to preside over the windswept dunes of St. Pete Beach, drawing guests with promises of ocean views and epic sunsets. The setting is so iconic, in fact, that movies like Once Upon a Time in America feature scenes with The Don in the background. The 241 contemporary rooms and 36 suites boast coastal charm, with crisp white linens and louvered windows accented by pops of turquoise and peacock blue. Two outdoor heated pools, a private beach, a game room, and complimentary bicycle rentals keep families entertained, while an 11,000-square-foot spa caters to couples seeking romance. When hunger strikes, guests have their pick of everything from a casual cafe, traditional beach bar, and nostalgia-inducing ice cream parlor, to a poolside grill and award-winning restaurant serving local produce and seafood.

Fans of real-deal sushi-bar Nipponese are united in huzzahs for Rokai, a sliver of a restaurant in a low-key, high-end section of the Cuauhtémoc quarter, north of the Reforma. Japanese-born chefs Hiroshi Kawahito and Daisuke Maeda change up the menu daily, depending on what’s available at markets (they make great use of some of the best fish that comes in from Baja California); regulars like to nosh omakase-style for a multiple-course tasting at the chef’s discretion. Quality sakes add a rosy glow to the precision with which every creation comes over the bar in this spare but fashionable setting. Reservations are recommended.

The past is present at Quinta Real, a colonial-style hacienda set in a residential neighborhood 20 minutes from downtown Guadalajara. In keeping with history, the property features soaring stucco ceilings, stone archways covered in crawling ivy, and wrought-iron balconies overlooking manicured gardens and cobblestone walkways. The story is the same inside, where 76 spacious suites are decorated with ornate Corinthian columns, well-curated antiques, and a palette of soothing ochres and greens. Like other hotels in the area, the Quinta Real has a swimming pool, butler and valet services, and a business center, but it’s the international dishes at Tierra Mia restaurant that are truly worthy of the hotel’s five-star rating.

SUR Beach House is everything a beach retreat ought to be. This chic Medano Beach property offers a relaxed, almost private-residence feel. Breakfasts range from healthy, green, and juicy to the indulgent croque madame. Pair any meal with a handcrafted cocktail; the SUR Caesar is a nice play on the classic Canadian cocktail and comes with crispy rib eye tips and roasted habanero sauce. The raw bar is like a love letter to the sea. Not least of all, the kitchen turns out delightful oyster preparations, but don’t leave Cabo without trying the raw chocolata clams. Named for their color, not their flavor, these meaty mollusks are best with just a little lime and hot sauce. (Come early for stand-up paddleboarding; Cabo SUP is located on-site and offers rentals as well as lessons.)

The custom-designed Jaguar Truck is a one-of-a-kind experience. After a scenic ride on the truck, you’re dropped off to ride a tandem bike through the jungle. Don’t worry about sweating; at the end of your ride awaits a natural pool, called a cenote (these pools were sacred to the Maya). Take a dip before heading onward to a beach, where you can indulge in more splash time before lunch is served.

The Hotel St. Francis lays claim to being Santa Fe’s oldest hotel. Rebuilt in its current location in 1924, after a fire left its predecessor completely ravaged (save the brick chimney), the property formerly known as the De Vargas Hotel played host to elegant ladies and gentlemen in top hats, politicos, and other VIPs during its heyday. After World War II, the hotel lost some of its luster, though it was still popular with government types until the 1960s. In 1986, new owners restored the hotel to its previous grandeur, replaced the barber and beauty shops with a restaurant and bar, and gave the property its current name. Most recently, in 2008, the property was purchased by Heritage Hotels and Resorts and underwent yet another makeover. Inspired by St. Francis, the patron saint of Santa Fe and founder of the Franciscan order, the look is best described as haute-monastic. Think Frette linens and flat-screen televisions paired with neutral hues, wood furnishings crafted by local artisans, and dim, candlelit common spaces.

Once known as Casa Cohen, Dôce 18’s eighteenth-century structure has been painstakingly restored and is now the city’s chicest forum for fashion, design, art, hotel-going and fine dining. Shopaholics go nuts, especially for the delicate, enigmatic bijoux at Sangre de Mi Sangre; fair-trade fashion at Amor y Rosas or the fabulous artisanal tablewares at Estanzuela. The on-site hostelry, L’Ôtel, is a claque of just ten impeccable habitats, exquisitely furnished, complete with rooftop pool. Restaurant Jacinto 1930 by Oaxacan chef Israel Loyola is the top table at this writing. Or kick the evening off with a tequila—we’re talking the good stuff—in the sleek Casa Dragones tasting room.

One of Mexico City’s most historic neighborhoods—a once-independent city-state politically joined to the Aztec capital of Tenochtitlan—Tlatelolco is a fascinating side trip few tourists make. At its center lies the district’s so-called Square of the Three Cultures, where a colossal public housing development (of revitalized interest to architecture buffs) surrounds a 17th-century Spanish church (notably embellished with stained-glass windows by 20th-century artist and architect Mathias Goeritz) as well as the ruins of pre-Hispanic Tlatelolco pyramids and other structures. In addition to being the exact spot on which the Aztec empire fell, the square was also the site where Mexican armed forces perpetrated a bloody 1968 massacre of university students and political activists. Tragedy aside, the area is still home to thousands of hardworking average Joes, and the community garden, known as the huerto, is pure down-home bucolic charm; it’s well worth a pop-in.

A few years ago, Bósforo was a nondescript bar in the capital’s Centro Histórico (Historic Center) neighborhood. Its decor was nothing to write home about; in fact, it was so dark it was hard to make out whether there was any decor to speak of. Fast forward to today, and the dark, dull interior hasn’t changed. Nor has the bar’s focus: mezcal. The smokier cousin of tequila is an agave-based spirit that has grown exponentially in popularity over the past several years. Most of the bar’s offerings are small-batch mezcals in bottles with handwritten labels. What you try today may not be available at all the next time you visit. What has changed in the past year or two is Bósforo’s visibility. Once a bar that was really only for locals in the know, Bósforo is now visited by mezcal lovers from all over the world. If you’re a fan of the spirit—or you haven’t yet tried it and would like to—Bósforo is worth a night out in the Centro.

Set behind a thick yellow facade with climbing green plants, Kinich offers mostly alfresco dining, with tables beneath palapa-style roofs. This popular restaurant has a fresh, elegant, not-too-touristy feel, and gets its share of locals. Yucatecan favorites make up the menu; the food is homemade, flavorful, and high-quality. Women in traditional dress grill tortillas as diners look on. The poc chuc (citrus-marinated pork) is delicious, especially when accompanied by a beverage made from a local plant, chaya, considered a superfood.

This ice-cream-and-sorbet parlor has been a favorite among locals for over a hundred years. It’s a great place to try sweet and refreshing frozen treats made from various stars of the Yucatán’s exotic-produce bonanza, such as sapote, mamey, and tamarind. At night, families fill the tables. Champolas—beverages crafted from milk and ice cream or sorbet—are also a favorite. A signature version includes sorbet made from soursop (guanábana), a fruit that abounds in the Yucatán.

Golfers will likely enjoy the Robert von Hagge–designed course at Marina Ixtapa, where saltwater inlets challenge players not only with their width but with a particularly interesting natural feature: crocodiles. If your ball slips into the drink, don’t go after it. Note that there’s limited shade on this course, so book a tee time early in the day. Repeat visitors also recommend hiring a caddy: Their services are affordable, and their course knowledge can help you improve your game.

From the outside, the Royal Ontario Museum appears to have been struck by a mineral formation from outer space. When the original building was overhauled by starchitect Daniel Libeskind, many locals were dismayed by the new addition, called the Michael Lee-Chin Crystal, but most have come around to its angular charms. Visitors to this museum of world cultures and natural history can work their way through galleries showcasing Chinese sculptures, Canada’s First Nations artifacts and crafts, dinosaur skeletons, and Byzantine artwork. Special exhibits have included everything from the intricate textiles of Mexico to an in-depth look at the culture of tattoos.

A wildly colorful, cartoonish emoji mural sets the scene for fun, fabulous Lalo, the casual-chic outpost from chef Eduardo García (whose Máximo Bistrot is adjudged one of the finest spots in the city). Tables for two are the first to fill, so diners usually find themselves at a long shared table, choosing from a menu of small(ish) plates that pack real flavor and cleverly blend familiar comforts with more-unusual, yet equally tempting, combinations. Breakfast faves include a sinful French toast or less conventional choices like chilaquiles in salsa verde; fluffy omelettes contain amazing cheeses and surprising ingredients. And don’t be shy with pastries. Lunch swings to raved-about pastas and pizzas, or the salad whose ingredients all come fresh from nearby Xochimilco. Artisanal beers and homemade sodas are a sensation as well.

Star chef Richard Sandoval recently opened Toro Latin Kitchen + Bar in nearby Punta Ballena. Try the spicy grab quacamole and the beef chicarron with a strawberry basil caipriñha. Get our complete list of Where to Go 2016 vacation ideas here.