My wife is from La Paz, and we try to visit the family in Bolivia at least once every two years. The first thing that strikes most visitors to La Paz is the altitude, of course. The city sits in a bowl high in the Andes mountains, and the altitude ranges from 10-13,000 feet above sea level. Denver may be the Mile High City, but La Paz is the Two Mile High City. The lowlands of Bolivia, including places like Santa Cruz, are much more tropical.