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Head to the edgy Santa Fe Railyard District—just a 20-minute walk from the plaza—to browse the various contemporary galleries that have taken up residence there. Stroll through the small parks, enjoy a meal at offbeat Southwestern eateries like La Choza and Tune-Up Café, and of course, visit the bountiful farmers’ market to check out the local produce and, in season, the famous Hatch green chile peppers.

The village of Santa Maria Atzompa is located about three miles from Oaxaca city, near Monte Alban archaeological site. This village has been producing pottery since ancient times, and today you can find a wide variety of pieces, from practical jugs and dishes to beautiful figurines and large decorative items. You’ll find a good selection of practical items, especially the green glaze ware that’s very popular, at the village co-op market. For finer pieces, seek out the artisans in their home studios.

On a typical day during Mykonos’s high season, you can see why Santa Marina has cemented its status as the ultimate jet-set destination. Megayachts bob in the bright blue waters of Ornos Bay, and a long pier lined with stylish couples curled up in cocoon-shaped sun chairs gives way to a stretch of sandy beach sprinkled with privileged bathers. In fact, the Santa Marina is the only hotel on the island with its own exclusive shoreline. Just steps away, the whitewashed property’s rooms climb a granite hill that looks out over the Aegean; expect a private balcony and marble bathroom in every space. Two restaurants, a bar, three pools, and a first-class spa and gym add to the country-club atmosphere, especially for those who might have their mini-me’s (wearing baby designer duds) in tow: The underage crowd has a dedicated pool, playground, and supervised kids’ club.

Catch the train from Genova Brignole station to Santa Margherita Ligure (about a 30-minute ride, leaving every ~30 minutes) and walk down to the large dockside pedestrian area. You will see the bike rental station just a few steps away from the bus ticket kiosk. For ~5 euros, you can have a bike for the whole day—a perfect option for exploring the fantastic surroundings! While the roads are all paved, they are incredibly narrow, and cars tend to drive quickly. Just be aware and stay very close to the edge for your own safety. Portofino (a 15-minute ride) is a gorgeous town frequented by international tourists and stunning yachts in the summer months. Originally named for the schools of dolphins (Port’Delfino) that often pass this cove, the landscape around the village is breathtaking. If you come in the spring, you can ditch your bike to spend the day hiking the paths up to the perched fort and church, or simply enjoy a gelato while gazing at the quaint fishing boats in the marina.

Founded in the 9th century, Santa Maria della Scala was one of Europe’s first hospitals. It was also one of the first hospitals anywhere to disinfect its equipment and only stopped taking in patients in the 1980s. (The writer Italo Calvino died here in 1961.) The early history of the hospital is illustrated in the 15th-century frescoes decorating the walls of the Pilgrim’s Hall, and there is a fascinating archaeological museum housed in the labyrinthine basement rooms.

From May to August, a ferry runs from the port of San Sebastián to the island that sits serenely in the middle of the Concha Bay. The island is quiet, isolated, and empty. There is a café on the island with a mysterious timetable, and a lighthouse that makes for a picturesque snapshot. Grab a loaf of bread, some cheese and ham, and settle down for a picnic and a reverse view of San Sebastián.

Built into rocky cliffs that tumble down to the sea, Hotel Santa Caterina is the embodiment of Amalfi Coast dreams. Bougainvillea blooms adorn corners of the 19th-century mansion, while lush terraced gardens teem with citrus trees and vine-covered pergolas. Public spaces are decorated in an elegant Mediterranean style, peppered with antique pieces and sweet details such as hand-painted majolica tiles, while light-filled guest rooms and suites feature Bulgari toiletries and balconies with sea views. Elevators are on hand to whisk guests down to the beach and a saltwater pool, where chic loungers and parasols line a stone sundeck and uninterrupted vistas lurk around every corner. You’ll find classic Italian fare and fresh seafood on the menu at the beachside bar as well as two restaurants, both of which spill out onto terraces. Even the spa offers a dose of local flavor with a signature Amalfi gold lemon massage. The Gambardella family has owned the property for generations, which may account for the consistently charming service and the loyalty of guests, who return year after year.

Built between 1914 and 1916 on an octagonal base, this stone, double-lens lighthouse is Aruba’s marquee landmark. Standing tall at 98 feet, it’s the highest structure on the island and offers the best views in its respective area. It gets its name from the SS California, a British steamship that sank in nearby waters in 1891 and now functions as a fantastic dive site. Adjacent to the lighthouse, visitors will find a beloved Italian restaurant and the California White Sand Dunes, a hot spot for dune surfing.

This Neoclassical building from the mid-19th century stands at one end of a large urban park. The interior of the Capitol is worth a visit—its rotunda and historic rooms reflect the history of lawmaking and governing in this state. The small exhibits from every California county highlight the natural beauty and local specialties from all parts of the state. They line the downstairs addition, which is enhanced with Art Deco details and includes the governor’s office. Outside the Capitol is Capitol Park, one of my favorite outdoor spaces in Sacramento. The paths wind past trees from all over the world (a map is available), memorials, a succulent garden, and a rose garden at the other end of the park.

The California Academy of Sciences is an unfortunately stuffy name for an institution that is anything but staid. The country’s largest natural-history museum includes an aquarium, a planetarium, an enormous rain-forest exhibit under a 27-meter-tall (90-foot-tall) dome, and a living roof that looks like a science-fiction fantasy. A visit here can feel like a trip to an amusement park, with a series of attractions to check out, but all of them are educational. The building itself is part of the appeal of the Academy. (Like the nearby de Young, the old home of the California Academy of Sciences was damaged in the 1989 Loma Prieta earthquake, and starchitect Renzo Piano designed its very environmentally friendly replacement.) It would be easy to spend an entire day or more seeing all of the Academy’s exhibits, so be prepared to pick and choose among them.

Located about an hour from Medellín, Santa Fe merits a detour for its lovely, well-preserved colonial architecture. The town was Antioquia province’s capital before Medellín, from 1584 until 1826, and time seems to have stopped here amid cobblestoned streets and whitewashed structures. Horseback tours lead to nearby waterfalls and the Cauca River.

Including more than 500 different vendors, the Santa Marta Market (Mercado Público) is a lively and colorful experience. You can wander among the exotic fruits and vegetables in one row of stores, see meat and poultry vendors in another and find gifts and clothing in a third section of the market. Even if you don’t find the perfect souvenir, exploring the market provides a glimpse into daily life in Santa Marta.

While the Barcelona Cathedral may be the city’s more famous church, Santa Maria del Mar is just as impressive, and a masterpiece of Catalan Gothic style. The basilica was built in just 54 years—begun in 1329 and completed in 1383—and its interior is austere but architecturally dazzling. Slender 60-foot-high columns set far apart from one another give the impression of lightness and space, while the enormous, brilliantly colored stained-glass rose window at the church’s western end allows sun to flood the space. Guided tours of the rooftop are conducted for 8 euros (about $9). The church also hosts regular classical concerts.

There are nearly as many snorkeling options in Los Cabos as there are fish in the Sea of Cortés, and that’s saying a lot. If you’re somebody who prefers going it alone, pick up a snorkeling mask and fins and head to Chileno Bay for some undisturbed fish-seeing. But if you need a little more hands-on guidance, the outfit to dial is Pez Gato. Their twice-daily, four-hour tour includes everything you’ll need—snorkeling gear, drinks, fresh fruit, and sandwiches—plus a friendly and knowledgeable crew who will keep you entertained with facts about the region as you navigate the waters to Santa Maria, a horseshoe-shaped bay that’s home to a marine sanctuary and some of the clearest waters around.

From coastal luxury to desert escapes, these ten iconic locations will guide you through the heart of Southern California.