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Little-known fact: New Orleans was the first place in North America to license pharmacists (starting in 1769, when the city was still under Spanish rule). After Louisiana became a territory, the U.S. governor extended the requirement, also decreeing that pharmacists take a three-hour licensing exam in order to practice. And no wonder illness got such attention—the city was arguably the least healthy place to live on the continent; it was riddled with yellow fever, malaria, and dysentery. This dark but fascinating history is explored in this atmospheric 1822 town house, which was once the home and shop of Louis J. Dufilho, the first licensed pharmacist in the city—and hence in the country. Exhibits include apothecary jars, tools of the trade, and leeches. (Yes. Leeches.)

On weekends, Iqbal Ali leads tours that bring another side of the city to life.

A handsome pueblo revival adobe building with a peaceful garden and courtyard, the New Mexico Museum of Art mounts small, rotating exhibits from its impressive 20,000-piece permanent collection. It includes well-known artists like Georgia O’Keeffe, Gustave Baumann, and members of the Taos Society of Artists (Ernest L. Blumenschein, Bert G. Phillips, Joseph H. Sharp), and noted 20th-century Southwest photographers like Ansel Adams. Don’t miss the special exhibits or the free Friday evenings (5–8 p.m.). The adjoining gift shop is a great place to pick up books, postcards, and jewelry.

Owned by the world-renowned art collector Dakis Joannou and smartly decorated by quirky Brazilian designers the Campana brothers, the New Hotel is the city’s coolest upscale design-centric property, with 79 rooms (including seven suites) and an intimate restaurant. Although centrally located, just a five-minute walk to Syntagma Square, it’s tucked back in a modernist building on a side street so it feels hidden and discreet. The interiors are both playful and smart; the Campanas created much of it with items recycled from the previous hotel. Imagine puzzlelike walls and chairs constructed of layered, repurposed wood intermingled with sculptural chairs of their own design. In the rooms, they had fun riffing on Greek cultural objects, like the Karagiozis, a shadow puppet, and multiple versions of the glass “evil eyes” used to protect against ill omen. Bottom line: stylish contemporary design, excellent location, and friendly service.

With more than 250 acres of grounds, the New York Botanical Garden manages to fit a number of different landscapes and experiences into its garden walls. The garden was established in 1891, the inspiration of Nathaniel Lord Britton and his wife, Elizabeth, who returned from a trip to England determined that New York should have its own equivalent to London‘s Kew Gardens. They found backing among New York society and created one of the country’s leading research institutions that also happens to be an ideal place to commune with nature right in the city. The rose garden designed by Beatrix Farrand is a highlight, while an abundance of azaleas reaches their peak in May. In all there are some 20 different gardens, including one dedicated to native plants, a rock garden, and a wetlands trail. The conservatory, constructed in 1902, is the largest in the country and includes 11 different climatic zones. When the last of the fall foliage has fallen from the trees, the conservatory hosts the popular annual Holiday Train Show (from the end of November to mid-January).

Unlike many of the cookie-cutter Vietnamese restaurants in Hanoi, there’s a good reason why many tour groups are brought here for their lunch. There are a la carte menus on offer, but most guests prefer to opt for the “popular” meal, which involves pointing at steaming vats containing things like Chinese braised pork and fat juicy ribs.

A local friend recommended Cake Cafe in the Bywater, so a friend and I stopped for lunch after exploring all afternoon. The humble bakery has some of the best sandwiches I’ve ever had, including my favorite, the crab sandwich, pictured here. It’s challah bread with crab meat, brie, bacon and spinach. It seems like a steep price for a sandwich, but worth every bite. Cake Cafe started as a bakery that sold all manners of sweets, but specialized in king cake, a Mardi Gras tradition. They became so popular that the store expanded to include other food items. Whatever you order, be sure to finish it off with dessert.

The main branch of the New York Public Library is one of the country’s grandest Beaux Arts buildings, a temple to learning on Fifth Avenue between 40th and 42nd streets. At the end of the 19th century, John Bigelow, who oversaw the Tilden Trust, decided that as New York was becoming a global financial capital, it required a grand public library. When the Astor and Lenox libraries faced financial difficulties, he convinced them to merge and, with the Tilden Trust, underwrite the library that now stands next to Bryant Park. The firm of Carrère and Hastings was entrusted with the design, and construction began in 1902 on the building that would be the largest marble structure built up to that time in the United States. The elegant main reading room with its soaring carved-wood ceilings is the highlight of its interiors. The library hosts temporary exhibitions related to literary and cultural topics that draw on its extensive collection of books and other printed materials. The two beloved lions in Tennessee marble—Patience and Fortitude—have stood at the entrance to the library since it opened in 1911 and were created by sculptor Edward Clark Potter.

This popular museum showcases a permanent exhibit of all things dinosaurs including rare finds and Jurassic era life-size replicas. It’s like walking back into time, a scene out of Jurassic Park -dating back a mere 200 million years ago. There’s also a naturalist center and a walk-through simulated volcano. The museum’s advanced planetarium, a full dome theatre, is where the live action happens. Don’t miss “Enchanted Skies,” a very cool look at constellations, planets and the far, deep sky.

New river cruises in India along the Ganges, Brahmaputra, and Hooghly rivers focus on wildlife encounters, centuries-old history, and life along the banks.

The new Oberoi Vindhyavilas offers world-class luxury while giving you prime access to Bandhavgarh Tiger Reserve.

Consider this your permission slip to take a trip before peak season hits.

Major added bonus: With more than 35 new routes from the USA to Europe launching this year, transatlantic airfares are finally expected to be more competitive.

After an escalation in tensions between India and Pakistan, this is the situation on the ground and what travelers should know.

These design-driven museums and hotels—plus a library, airport, and aquarium—are practically works of art.