The contemporary art scene in every city is different. The cluster of galleries in each neighborhood reflects the mentality of its residences and the crowds it naturally attracts. The art scene in Bushwick, NY is noticeably different than the art scene in Lower East Side Manhattan, even though the neighborhoods are separated by a short 15 minute ride on the subway.
The gallery of note in both curation and significance is Xavier Hufken. This is a blue chip gallery with excellent programming and occupying an incredible space. It is everything you expect it to be. The space is lovely and the shows are expertly curated.
I particularly love the Anthony Gromley exhibit I saw there. Gromley might not be up by the time you make your way there, but I am sure whichever artist Hufken is presenting will be stellar.