Want to sleep next to the mythical birthplace of the ancient Incan empire? Book a night at Titilaka, a boutique hotel on the shores of Lake Titicaca, the largest lake in the Andes. Flanked on three sides by quinoa farms and red sandstone peaks, the property opens onto a 118-mile horizon of fresh water. As part of my stay, local kayak guide Armando Suaña brought me to nests of indigenous grebes and ducks, and farther offshore to his family’s own manmade island, one in a flotilla of thatched reed rafts that the Uros people have called home for the last 500 years. —Daniel Grushkin
Titilaka, (866) 628-1777, from $910. This appeared in the May/June 2010 issue.