Synonymous for over a decade with trendy clubs, flocks of stiletto-clad models, and pricey boutiques, the Meatpacking District is going through another metamorphosis. Stroll the atmospheric cobblestone streets—past fashion temples like Stella McCartney, Christian Louboutin, and Marc Jacobs—to the recently unveiled downtown branch of the Whitney Museum. It’s a gorgeous Renzo Piano-designed landmark devoted to American art, set right beneath the southern entrance to The High Line. The museum also features a notable new restaurant, Untitled, helmed by chef Michael Anthony of Gramercy Tavern. When you've had your art fix, wander the length of the High Line, the elevated railway-turned-world class green space that doubles as one of the city's most enjoyable people-watching destinations.