Situated in the historic, leafy West End—what some consider to be Portland’s prettiest area—this red-brick Federal-style mansion has been home to a Prohibition-era hideout, a boarding school, and for the past two decades, the intimate, elegant Danforth Inn. Its nine rooms are each uniquely furnished with a mix of modern European pieces and Asian influences as well as nearly a million dollars’ worth of modern art on display. A small garden blooms with lilacs, fragrant herbs, and edible flowers in the spring and summer, while 13 working fireplaces—there’s one in each room and two in the West End Suite—make for cozy evenings come fall and winter. After a renovation completed in 2015, Tempo Dulu, a 36-seat Southeast Asian restaurant, opened with dishes like grilled lobster with spring onion cake and dramatic design accents such as a live-moss chandelier. In 2017, the inn expanded on the Asian theme with Opium; decor is meant to invoke a 1920s Shanghai speakeasy, and cocktails include the Danforth Swizzle, a rum-based drink accented with Chinese five spice–infused bitters.