Calle 8 Este con, Av. B, Panamá, Panama
Photo courtesy of Tantalo Hotel
Tantalo HotelLocated in Casco Viejo, Tantalo Hotel is a great home base for exploring Panama City. Rooms here are entirely unique, each one featuring work by a different local artist as well as colorful, modern décor and spacious rain showers. When hunger strikes, head to the solid onsite restaurant (get the ceviche), or the stylish rooftop bar, where you can sip watermelon margaritas while enjoy sweeping views across the bay. At night, it’s the place to be, with local partygoers flooding in as soon as the sun goes down.