The bus ride from Santiago to Mendoza
We didn't know what to expect but we knew we wanted to take the bus from Santiago to Mendoza. The route leads you over the Andes and after many turns (we stopped counting at 30), you descend into Argentina and end up in wine country. It's about an 8 hour bus ride with 1 stop at the border. They show movies and provide snacks. The real show, however, is the ascent to the top. It's breathtaking. The landscape makes you feel like you are on the moon. If you have the time, I recommend this route.
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