Contemporary and central, the O&B Boutique hotel is easily accessible to Athens’ major sites—the Parthenon is about a 15-minute walk—while also handy to pedestrian shopping streets and nightlife in Psiri. Some guests might find the area’s graffiti off-putting, but the neighborhood is safe and friendly behind its gritty appearance. Rooms have neutral color palettes—the name refers to the colors ochre and brown—with accents of orange, wood floors, and views of the Athens observatory and Thissio’s neoclassical architecture. Upgrade to a suite for a private terrace with views of the Parthenon. The Thissio and Monastiraki metro stations are within a few minutes’ walk, connecting to Syntagma Square and the port at Pireaus. The all-day restaurant serves a complimentary breakfast buffet for hotel guests, with fresh bread, cheese and Greek yogurt.