Located about 30 minutes outside of Mérida, this five-star wellness retreat, spread across 750 acres, combines sleek and sumptuous modernity with a mystical flair. Maybe it’s the jungle setting, which oozes with lush tropical greenery and enchanting gardens. Or perhaps it’s the spa’s cenote, a sacred cavern and source of mystical energy, and its healing treatments inspired by ancient Mayan techniques and traditions. For some, mysticism comes by sampling the hotel’s tequila collection—the world’s largest, with over 1,000 varieties—or indulging in chef Jorge Vallejo’s inspired fare at three on-site restaurants, with seasonal ingredients culled straight from the hotel’s own organic Mayan gardens. Or maybe it’s the casitas and villas themselves, which, nestled within gardens, incorporate the old walls of this former 19th-century hacienda into modern architecture and contemporary decor. Each has a private pool, complete with hammocks swinging above the water and outdoor showers; for a true splurge, book the lavish three-bedroom Royal Villa, which has a massive pool, a hot tub, a bar, and even a private gym.