Sitting beside the main cathedral in Old Town, Casa Pombo is among the oldest homes in the city. Its foundation dates to Cartagena’s early days in the mid-1500s, and past owners include Don Manuel de Anguiano, an army hero during Colombia's war for independence. This rich history is told through original colonial features, like coralline stone arches and floors seen throughout the estate. But the small details of this property are just as memorable: Sunlight filters through an interior courtyard; exposed-wood beams enhance guest-room ceilings; wicker baskets filled with towels rest beside a rooftop pool. Along with guest rooms there are vast two-, three-, and four-bedroom apartments. Units have modern open-plan kitchens and are individually—and sparingly—decorated with a mix of modern and antique furniture, light colors, and earthy materials, allowing original architectural features to shine. It's an altogether stunning place, and its location within a short walk of some of the city's best fine-dining and nightlife spots doesn't hurt either.