There are not very many roads through the interior of Alaska, and even fewer rail lines. The main Alaska Railroad line runs from Seward, through Anchorage, to Fairbanks, through pristine Alaskan wilderness. Breathtaking views of Denali (Mount McKinley), native villages and diverse Alaskan wildlife float by your window on the twelve hour trip. For the heartier souls looking to embark on a Denali trek, the train stops in Talkeetna, the gateway to Denali National Park (and the inspiration for the fictional town of Cicely on TV's "Northern Exposure"). But if you aren't a hard core outdoorsman, this train will still get you pretty close to these wild wonders, and it will do it in warmth and comfort. The friendly conductors even slow the train and announce the best spots to photograph Denali, and shout out when wildlife make an appearance alongside the tracks. This train is also the last railroad in the U.S. that does "flag stops" to pick up locals who live out in the icy interior who "flag" down the train along its route. The train runs once a week in each direction in the winter months, and daily in the summer.