With its prime setting on the Grand Canal, the 15th-century Venetian Gothic palazzo-turned- hotel was for years the go-to getaway for such cultural luminaries as Ernest Hemingway and Julian Schnabel. Its recent $45 million restoration has intensified its old-world glamour. The most over-the-top of the 82 units (fewer than before, but bigger) are the redesigned suites: The Pisani Palazzo Canal Suite (pictured) has ceiling cornices painted with Venetian rococo motifs. It also features Murano chandeliers, gilded mirrors, heritage terrazzo flooring, and historic oil paintings. Doubles from $635. Campo Santa Maria del Giglio, 39/041-794-611. This appeared in the October 2013 issue.