Tantalo is a great home base in Casco Viejo. It has everything you need and is a cool spot on top of that. The rooms are all totally unique—each one is designed by a different local Panamian artist. They're colorful, modern, spacious, and feature rain showers. The first floor has a solid restaurant (try the house ceviche), a little bar with local brew on tap (Balboa and Atlas), and fast, free Wi-fi. And, to boot, it has an awesome rooftop bar, with views over historic Casco Viejo and the soaring skyscrapers of Panama City across the bay. At night, it's definitely the place to be, with partygoers pouring in as soon as the sun goes down. The coconut mojitos are not to be missed. The staff is exceptionally nice as well—and they'll likely end up on the roof with you by the end of the night. The fun vibe here is infectious.