Century-old La Casona estancia lies on the expansive estate of Matetic Vineyards, known for its syrah, about 60 miles west of Santiago. Spacious rooms feature wooden floors, cozy reading chairs, and French doors that open onto the organically farmed property. Bike between the vines, take a horseback ride through the surrounding Rosario Valley with a huaso (cowboy) guide, or visit Pablo Neruda’s house in nearby Isla Negra. —Tom Colligan
La Casona. From $370. 56/(0) 2-585-8197. This appeared in the September/October 2011 issue. See more vineyard hotels.