Located in the popular Heritage Green district of downtown Greenville, the art museum houses a robust collection of American art. The museum's permanent collection of Andrew Wyeth watercolors and Jasper Johns prints and paintings make the place an artistic destination in the South. Greenville's multitude of art students benefit from these works as well as the museum's regular exhibitions.
One highlight of the year is the annual Antiques, Fine Art & Design Weekend. Dealers from across the U.S. gather to put on this exciting event each October.