by Jocelyn C. Zuckerman

Famed French architect Jean Nouvel gets credit for the bold exterior, while a different design studio dreamed up each of the hotel’s 12 floors. Step out on the seventh to find Ron Arad’s space-age curves, on the 10th for the minimalism of Arata Isozaki, or on the 11th for Javier Mariscal and Fernando Salas’s animal-pelt walls.

See more art hotels in Rome, New York City, Dublin, Hong Kong, and Argentina.

From $170. 34/917-445-400, hoteles-silken.com. This story appeared in the November/December 2011 issue. Photos courtesy of Hotel Silken.